Androgen Receptor antibody (N-Term)

Catalog No. ABIN6971389

Product Details anti-Androgen Receptor Antibody

Target: Androgen Receptor (AR)

Binding Specificity: N-Term

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Androgen Receptor antibody is un-conjugated

Application: Western Blotting (WB), Chromatin Immunoprecipitation (ChIP), ChIP DNA-Sequencing (ChIP-seq)

Characteristics: Androgen Receptor (AR, NR3C4) is a nuclear receptor that facilitates signaling of testosterone and other androgenic hormones in the cytoplasm and translocates into the nucleus upon hormone binding. AR serves as a DNA binding activator of transcription of hormone responsive genes. There are two forms of the Androgen Receptor, the AR-A form, lacking the N-terminal 187 amino acids and the full length AR-B form. Androgen Receptor is involved in the development of both primary and secondary male sexual characteristics and abnormal expression of AR is linked to prostate cancer. Androgen Receptor antibody (pAb) was raised in a Rabbit host. It has been validated for use in Chromatin Immunoprecipitation, ChIP-Seq and Western blot, it has been shown to react with Human and Mouse samples.

Purification: Protein A Chromatography

Immunogen: This Androgen Receptor antibody was raised against a peptide in the N-terminal region of human Androgen receptor.

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Buffer: PBS pH 7.5 containing 30 % glycerol and 0.035 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20°C for up to 2 years. Keep all reagents on ice when not in storage.

Target Details for Androgen Receptor

Target: Androgen Receptor (AR)

Alternative Name: Androgen Receptor (AR Products)

Synonyms: AIS antibody, DHTR antibody, HUMARA antibody, HYSP1 antibody, KD antibody, NR3C4 antibody, SBMA antibody, SMAX1 antibody, TFM antibody, AW320017 antibody, Tfm antibody, Andr antibody, AR antibody, androgen receptor antibody, AR antibody, Ar antibody, ar antibody

Molecular Weight: 110 kDa

NCBI Accession: NP_000035

Pathways: Nuclear Receptor Transcription Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Steroid Hormone Mediated Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Nuclear Hormone Receptor Binding, Chromatin Binding