Factor VIII antibody

Catalog No. ABIN1820031

Product Details anti-Factor VIII Antibody

Target: Factor VIII (F8) (Coagulation Factor VIII (F8))

Reactivity: Human, Pig

Host: Mouse

Clonality: Monoclonal

Conjugate: This Factor VIII antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Radioimmunoassay (RIA)

Specificity: Recognizes human Factor VIII, an essential blood coagulation factor. Whilst circulating in the blood, it is mostly stably complexed to von Willebrand factor. It is activated through cleavage at various sites, dissociates from the complex and interacts with Factor IXa, in the presence of calcium ions and phospholipids, to convert Factor X to the activated Factor Xa, which activates thrombin. Thrombin cleaves fibrinogen into fibrin, which polymerises and cross-links to form a blood clot. The activated Factor VIII is proteolytically inactivated and cleared from the bloodstream. Defects in Factor VIII cause hemophilia A, a disorder characterized by the body's inability to control blood clotting. This could result in severe blood loss, even with minor injuries. Clone RFF-VIIIC/8 is a very potent coagulation inhibitor. It recognizes an epitope towards the N-terminus of full-length Factor VIII. It also recognizes the 210kD, 90kD and 40kD cleavage products. This clone does not cross-react with von Willebrand factor.

No Cross-Reactivity: Mouse (Murine), Dog (Canine), Rat (Rattus)

Purification: Protein G purified

Immunogen: Affinity purified human Factor VIII.

Type of Immunogen: Purified protein

Clone: RFF-VIIIC-8

Isotype: IgG1

Application Details

Application Notes: Approved: ELISA (1:500 - 1:15000), RIA, WB

Comment:

Target Species of Antibody: Human

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: PBS, 0.09 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: 4°C or -20°C, Avoid freeze-thaw cycles.

Target Details for Factor VIII

Target: Factor VIII (F8) (Coagulation Factor VIII (F8))

Alternative Name: F8 / FVIII / Factor VIII (F8 Products)

Synonyms: fb61d02 antibody, wu:fb61d02 antibody, Cf-8 antibody, Cf8 antibody, FVIII antibody, AHF antibody, DXS1253E antibody, F8B antibody, F8C antibody, HEMA antibody, coagulation factor VIIi antibody, coagulation factor VIII antibody, coagulation factor VIII, procoagulant component antibody, f7i antibody, F8 antibody

Background: Name/Gene ID: F8

Synonyms: F8, AHF, Antihemophilic factor, Coagulation factor VIIIc, Coagulation factor VIII, DXS1253E, Factor VIII F8B, FVIII, HEMA, F8B, Factor VIII, Procoagulant component, F8C

Gene ID: 2157