HEY1 antibody (C-Term)

Catalog No. ABIN182593

This Rabbit Polyclonal antibody specifically detects HEY1 in WB and IHC. It exhibits reactivity toward Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse and Rabbit.It has been mentioned in 1 publication

Quick Overview for HEY1 antibody (C-Term) (ABIN182593)

Target: HEY1 (Ha-Ry/enhancer-of-Split Related with YRPW Motif 1 (HEY1))

Reactivity: Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HEY1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-HEY1 Antibody

Binding Specificity: C-Term

Sequence: PQNGHGNAGT TASPTEPHHQ GRLGSAHPEA PALRAPPSGS FGPVLPVVTS

Predicted Reactivity: Cow: 79%, Dog: 86%, Guinea Pig: 93%, Horse: 93%, Human: 100%, Mouse: 93%, Rabbit: 79%, Rat: 93%

Characteristics: This is a rabbit polyclonal antibody against HEY1. It was validated on Western Blot and immunohistochemistry.

Purification: Protein A purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human HEY1

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 304 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

References for anti-HEY1 antibody (ABIN182593)

Zhang, Weimann, Stolzenburg, Neuhaus, Berndt-Paetz: "Notch2/3-DLL4 interaction in urothelial cancer cell lines supports a tumorigenic role of Notch signaling pathways in bladder carcinoma." in: PloS one, Vol. 20, Issue 2, pp. e0317709, (2025) (PubMed).

Target Details for HEY1

Target: HEY1 (Ha-Ry/enhancer-of-Split Related with YRPW Motif 1 (HEY1))

Alternative Name: HEY1

Background: Hairy/enhancer of split-related proteins, such as HEY1, are basic helix-loop-helix (bHLH) transcription factors implicated in cell fate decision and boundary formation. HEY genes are direct transcriptional targets of the Notch signaling pathways in Drosophila and vertebrates.
Alias Symbols: CHF2, OAF1, HERP2, HESR1, HRT-1, BHLHb31
Protein Interaction Partner: SYVN1, DERL2, HEY2, SEL1L, PRKD2, LAPTM5, SKIL, SMAD9, SMAD3, ARNT, NOTCH1, ELAVL1, FBXW7, HEY1, GATA1, MYOD1,
Protein Size: 304

Molecular Weight: 33 kDa

Gene ID: 23462

NCBI Accession: NM_012258, NP_036390

UniProt: Q9Y5J3

Pathways: Tube Formation