CD226 antibody (Biotin)

Catalog No. ABIN1839602

The Mouse Monoclonal anti-CD226 antibody has been validated for FACS and IP. It is suitable to detect CD226 in samples from Human.

Quick Overview for CD226 antibody (Biotin) (ABIN1839602)

Target: CD226

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This CD226 antibody is conjugated to Biotin

Application: Flow Cytometry (FACS), Immunoprecipitation (IP)

Clone: DX11

Product Details anti-CD226 Antibody (Biotin)

Specificity: Recognizes human CD226, a 65kD glycoprotein, also known as DNAM1 (DNAX accessory molecule-1). CD226 is broadly expressed on T-cells, NK cells, platelets, monocytes and a subset of B cells. CD226 is also expressed by a subset of CD3 positive thymocytes. Clone DX11 is reported to inhibit T- and NK cell mediated cytotoxicity against tumor cell targets and to block TNF alpha and IFN gamma secretion by alloantigen-specific T-cells (3).

Purification: Purified

Immunogen: Human cytotoxic T lymphocyte clone.

Type of Immunogen: Cells

Isotype: IgG1

Application Details

Application Notes: Approved: Flo, IP

Usage: The applications listed have been tested for the unconjugated form of this product. Other forms have not been tested.

Comment:

Target Species of Antibody: Human

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: PBS, 0.09 % sodium azide, 1 % BSA

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C,-20 °C

Storage Comment: Short term: 4°C. Long term: Store at -20°C. Avoid freeze-thaw cycles.

Target Details for CD226

Target: CD226

Alternative Name: DNAM-1 / CD226

Background: Name/Gene ID: CD226

Synonyms: CD226, Adhesion glycoprotein, CD226 Molecule, CD226 antigen, DNAM-1, DNAM1, DNAX accessory molecule-1, TLiSA1, PTA1, DNAX accessory molecule 1

Gene ID: 10666

UniProt: Q15762

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Cancer Immune Checkpoints