serpin Peptidase Inhibitor, Clade I (Pancpin), Member 2 (SERPINI2) (Internal Region) antibody

Details for Product No. ABIN185374, Supplier: Log in to see
Antigen
  • Spi14
  • MEPI
  • PANCPIN
  • PI14
  • TSA2004
  • serpin family I member 2
  • serpin peptidase inhibitor, clade I (pancpin), member 2 L homeolog
  • serpin peptidase inhibitor, clade I (pancpin), member 2
  • serine (or cysteine) peptidase inhibitor, clade I, member 2
  • SERPINI2
  • serpini2.L
  • Serpini2
Epitope
Internal Region
11
10
9
7
3
3
3
1
1
1
1
Reactivity
Human
79
31
26
7
5
5
4
3
3
2
1
Host
Goat
57
16
7
2
Clonality
Polyclonal
Conjugate
Un-conjugated
5
4
4
3
3
3
1
1
1
1
1
1
1
1
1
1
1
Application
Immunohistochemistry (IHC), ELISA, Western Blotting (WB)
65
38
15
13
8
1
1
Options
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Purpose MEPI / SERPINI2
Immunogen Peptide with sequence C-KGDWKQKFRKEDTQ, from the internal region of the protein sequence according to NP_006208.1, NP_001012303.1.
Blocking Peptide Blocking peptide for this product available: ABIN369274
Sequence KGDWKQKFRK EDTQ
Specificity This antibody is expected to recognise both reported isoforms (NP_006208.1, NP_001012303.1).
Predicted Reactivity Human, Mouse, Rat, Dog
Purification Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Grade Verified
Antigen
Alternative Name SERPINI2 (SERPINI2 Antibody Abstract)
Background SERPINI2, MEPI, PI14, PANCPIN, TSA2004, SERPIN12, serine (or cysteine) proteinase inhibitor, clade I (neuroserpin), member 2, serpin peptidase inhibitor, clade I (pancpin), member 2, myoepithelium-derived serine protease inhibitor, protease inhibitor 14, serine (or cysteine) proteinase inhibitor, clade I (pancpin), member 2
Gene ID 5276
NCBI Accession NP_006208, NP_001012303
Application Notes

DS WB Results: Approx 40 kDa band observed in Human Pancreas lysates (calculated MW of 46.1 kDa according to NP_006208.1 and 47.4 kDa according to NP_001012303.1). Recommended concentration: 0.3-1 μg/mL.

DS IHC Results: In paraffin embedded Human Pancreas, shows cytoplasmic staining of acinar cels and of rare cells in the islets of Langerhans. Recommended concentration, 3 μg/mL.

Peptide ELISA Statement: Peptide ELISA: antibody detection limit dilution 1:64000.

Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer Supplied at 0.5 mg/mL in Tris saline, 0.02 % sodium azide, pH 7.3 with 0.5 % bovine serum albumin.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Minimize freezing and thawing.
Storage -20 °C
Storage Comment Aliquot and store at -20 °C.
Supplier Images
 image for anti-serpin Peptidase Inhibitor, Clade I (Pancpin), Member 2 (SERPINI2) (Internal Region) antibody (ABIN185374) ABIN185374 (0.3µg/ml) staining of Human Pancreas lysate (35µg protein in RIPA buffer)...
Immunohistochemistry (IHC) image for anti-serpin Peptidase Inhibitor, Clade I (Pancpin), Member 2 (SERPINI2) (Internal Region) antibody (ABIN185374) ABIN185374 (3µg/ml) staining of paraffin embedded Human Pancreas. Microwaved antigen ...
Product cited in: Wehr, Furth, Sangar, Blair, Yu: "Analysis of the human pancreatic stellate cell secreted proteome." in: Pancreas, Vol. 40, Issue 4, pp. 557-66, 2011 (PubMed).

Background publications Xiao, Liu, Gentz, Sang, Ni, Goldberg, Shi: "Suppression of breast cancer growth and metastasis by a serpin myoepithelium-derived serine proteinase inhibitor expressed in the mammary myoepithelial cells." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 96, Issue 7, pp. 3700-5, 1999 (PubMed).

Ozaki, Nagata, Suzuki, Fujiwara, Miyoshi, Ishikawa, Ohigashi, Imaoka, Takahashi, Nakamura: "Isolation and characterization of a novel human pancreas-specific gene, pancpin, that is down-regulated in pancreatic cancer cells." in: Genes, chromosomes & cancer, Vol. 22, Issue 3, pp. 179-85, 1998 (PubMed).

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