serpin Peptidase Inhibitor, Clade I (Pancpin), Member 2 (SERPINI2) (Internal Region) antibody

Details for Product No. ABIN185374, Supplier: Log in to see
Antigen
  • Spi14
  • MEPI
  • PANCPIN
  • PI14
  • TSA2004
  • serpin family I member 2
  • serpin peptidase inhibitor, clade I (pancpin), member 2 L homeolog
  • serpin peptidase inhibitor, clade I (pancpin), member 2
  • serine (or cysteine) peptidase inhibitor, clade I, member 2
  • SERPINI2
  • serpini2.L
  • Serpini2
Epitope
Internal Region
11
10
9
7
3
3
3
1
1
1
1
Reactivity
Human
79
31
26
7
5
5
4
3
3
2
1
Host
Goat
57
16
7
2
Clonality
Polyclonal
Conjugate
Un-conjugated
5
4
4
3
3
3
1
1
1
1
1
1
1
1
1
1
1
Method Type
Peptide ELISA
Application
Immunohistochemistry (IHC), ELISA, Western Blotting (WB)
65
38
15
13
8
1
1
Options
Supplier
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Immunogen Peptide with sequence C-KGDWKQKFRKEDTQ, from the internal region of the protein sequence according to NP_006208.1, NP_001012303.1.
Blocking Peptide Blocking peptide for this product available: ABIN369274
Specificity This antibody is expected to recognise both reported isoforms (NP_006208.1, NP_001012303.1).
Cross-Reactivity Mouse (Murine), Rat (Rattus), Dog (Canine)
Purification Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Antigen
Alternative Name MEPI / SERPINI2 (SERPINI2 Antibody Abstract)
Background Synonyms: SERPINI2, MEPI, PI14, PANCPIN, TSA2004, SERPIN12, serine (or cysteine) proteinase inhibitor, clade I (neuroserpin), member 2, serpin peptidase inhibitor, clade I (pancpin), member 2, myoepithelium-derived serine protease inhibitor, protease inhibitor 14, serine (or cysteine) proteinase inhibitor, clade I (pancpin), member 2
Gene ID 5276, 67931, 171149
NCBI Accession NP_006208, NP_001012303
Application Notes ELISA: antibody detection limit dilution 1:64000.
Western blot: Approx 40 kDa band observed in Human Pancreas lysates (calculated MW of 46.1 kDa according to NP_006208.1 and 47.4 kDa according to NP_001012303.1). Recommended concentration: 0.3-1 µg/mL.
IHC: In paraffin embedded Human Pancreas, shows cytoplasmic staining of acinar cels and of rare cells in the islets of Langerhans. Recommended concentration: 3 µg/mL.
Restrictions For Research Use only
Format Liquid
Buffer Supplied at 0.5 mg/mL in Tris saline, 0.02 % sodium azide, pH 7.3 with 0.5 % bovine serum albumin.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Minimize freezing and thawing.
Storage -20 °C
Storage Comment Aliquot and store at -20 °C.
Supplier Images
 image for anti-serpin Peptidase Inhibitor, Clade I (Pancpin), Member 2 (SERPINI2) (Internal Region) antibody (ABIN185374) ABIN185374 (0.3µg/ml) staining of Human Pancreas lysate (35µg protein in RIPA buffer)...
Immunohistochemistry (IHC) image for anti-serpin Peptidase Inhibitor, Clade I (Pancpin), Member 2 (SERPINI2) (Internal Region) antibody (ABIN185374) ABIN185374 (3µg/ml) staining of paraffin embedded Human Pancreas. Microwaved antigen ...
Product cited in: Wehr, Furth, Sangar, Blair, Yu: "Analysis of the human pancreatic stellate cell secreted proteome." in: Pancreas, Vol. 40, Issue 4, pp. 557-66, 2011 (PubMed).

Background publications Xiao, Liu, Gentz, Sang, Ni, Goldberg, Shi: "Suppression of breast cancer growth and metastasis by a serpin myoepithelium-derived serine proteinase inhibitor expressed in the mammary myoepithelial cells." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 96, Issue 7, pp. 3700-5, 1999 (PubMed).

Ozaki, Nagata, Suzuki, Fujiwara, Miyoshi, Ishikawa, Ohigashi, Imaoka, Takahashi, Nakamura: "Isolation and characterization of a novel human pancreas-specific gene, pancpin, that is down-regulated in pancreatic cancer cells." in: Genes, chromosomes & cancer, Vol. 22, Issue 3, pp. 179-85, 1998 (PubMed).

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