CBP antibody (AA 2216-2442)

Catalog No. ABIN1858492

Product Details anti-CBP Antibody

Target: CBP (CREBBP) (CREB Binding Protein (CREBBP))

Binding Specificity: AA 2216-2442

Reactivity: Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CBP antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP), Immunocytochemistry (ICC)

Purpose: Polyclonal Antibody to CREB Binding Protein (CREBBP)

Specificity: The antibody is a rabbit polyclonal antibody raised against CREBBP. It has been selected for its ability to recognize CREBBP in immunohistochemical staining and western blotting.

Cross-Reactivity: Human, Mouse

Purification: Antigen-specific affinity chromatography followed by Protein A affinity chromatography

Immunogen: Recombinant CREB Binding Protein (CREBBP) corresdonding to Gln2216~Leu2442 with N-terminal His Tag

Isotype: IgG

Application Details

Application Notes:

Western blotting: 0.5-2 μg/mL Immunohistochemistry: 5-20 μg/mL Immunocytochemistry: 5-20 μg/mL Optimal working dilutions must be determined by end user.

Comment:

The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: 0.01M PBS, pH 7.4, containing 0.05 % Proclin-300, 50 % glycerol.

Preservative: ProClin

Precaution of Use: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C for frequent use. Stored at -20°C in a manual defrost freezer for two year without detectable loss of activity. Avoid repeated freeze-thaw cycles.

Expiry Date: 24 months

References for anti-CBP antibody (ABIN1858492)

Thamizhoviya, Vanisree: "Enriched environment modulates behavior, myelination and augments molecules governing the plasticity in the forebrain region of rats exposed to chronic immobilization stress." in: Metabolic brain disease, Vol. 34, Issue 3, pp. 875-887, (2020) (PubMed).

Target Details for CBP

Target: CBP (CREBBP) (CREB Binding Protein (CREBBP))

Alternative Name: CREB Binding Protein (CREBBP Products)

Synonyms: CBP antibody, KAT3A antibody, RSTS antibody, AW558298 antibody, CBP/p300 antibody, p300/CBP antibody, RTS antibody, cbp antibody, crebbp antibody, kat3a antibody, rsts antibody, hmm291030 antibody, Nejire antibody, CREB binding protein antibody, CREB binding protein L homeolog antibody, histone acetyltransferase p300 antibody, CREBBP antibody, Crebbp antibody, crebbp.L antibody, LOC100123220 antibody

Background: CBP, RSTS, RTS, KAT3A, Rubinstein-Taybi Syndrome

Pathways: TCR Signaling, Interferon-gamma Pathway, Stem Cell Maintenance, Chromatin Binding, Regulation of Lipid Metabolism by PPARalpha