NCOA3 antibody (N-Term)

Catalog No. ABIN1881566

The Rabbit Polyclonal anti-NCOA3 antibody has been validated for WB. It is suitable to detect NCOA3 in samples from Human. There are 4+ publications available.

Quick Overview for NCOA3 antibody (N-Term) (ABIN1881566)

Target: NCOA3 (Nuclear Receptor Coactivator 3 (NCOA3))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NCOA3 antibody is un-conjugated

Application: Western Blotting (WB)

Clone: RB41497

Product Details anti-NCOA3 Antibody

Binding Specificity: AA 344-372, N-Term

Predicted Reactivity: Rat

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This NCOA3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 344-372 amino acids from the N-terminal region of human NCOA3.

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

References for anti-NCOA3 antibody (ABIN1881566)

Cai, Shames, Raso, Xie, Kim, Pollack, Girard, Sullivan, Gao, Peyton, Nanjundan, Byers, Heymach, Mills, Gazdar, Wistuba, Kodadek, Minna: "Steroid receptor coactivator-3 expression in lung cancer and its role in the regulation of cancer cell survival and proliferation." in: Cancer research, Vol. 70, Issue 16, pp. 6477-85, (2010) (PubMed).

Kovanen, Saarikoski, Haukka, Pirkola, Aromaa, Lönnqvist, Partonen: "Circadian clock gene polymorphisms in alcohol use disorders and alcohol consumption." in: Alcohol and alcoholism (Oxford, Oxfordshire), Vol. 45, Issue 4, pp. 303-11, (2010) (PubMed).

Karmakar, Gao, Pace, Oesterreich, Smith: "Cooperative activation of cyclin D1 and progesterone receptor gene expression by the SRC-3 coactivator and SMRT corepressor." in: Molecular endocrinology (Baltimore, Md.), Vol. 24, Issue 6, pp. 1187-202, (2010) (PubMed).

Bailey, Xie, Do, Montpetit, Diaz, Mohan, Keavney, Yusuf, Gerstein, Engert, Anand: "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study." in: Diabetes Care, Vol. 33, Issue 10, pp. 2250-3, (2010) (PubMed).

Target Details for NCOA3

Target: NCOA3 (Nuclear Receptor Coactivator 3 (NCOA3))

Alternative Name: NCOA3

Background: The protein encoded by this gene is a nuclear receptor coactivator that interacts with nuclear hormone receptors to enhance their transcriptional activator functions. The encoded protein has histone acetyltransferase activity and recruits p300/CBP-associated factor and CREB binding protein as part of a multisubunit coactivation complex. This protein is initially found in the cytoplasm but is translocated into the nucleus upon phosphorylation. Several transcript variants encoding different isoforms have been found for this gene. In addition, a polymorphic repeat region is found in the C-terminus of the encoded protein.

Molecular Weight: 155293

NCBI Accession: NP_001167559, NP_006525, NP_858045

UniProt: Q9Y6Q9

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Regulation of Lipid Metabolism by PPARalpha