CDKN1B antibody (Cyclin-Dependent Kinase Inhibitor 1B (p27, Kip1)) (pSer83)

Details for Product anti-CDKN1B Antibody No. ABIN1881622, Supplier: Log in to see
Antigen
  • CDKN4
  • KIP1
  • MEN1B
  • MEN4
  • P27KIP1
  • cdkn1b
  • sb:cb611
  • wu:fb63g10
  • wu:fb64g10
  • wu:fe18e03
  • CDKN1B
  • Kip1
  • p27
  • Cdki1b
  • AA408329
  • AI843786
  • p27Kip1
  • cdkn1bl
  • cyclin dependent kinase inhibitor 1B
  • cyclin-dependent kinase inhibitor 1Bb
  • cyclin-dependent kinase inhibitor 1B
  • cyclin-dependent kinase inhibitor 1Ba
  • CDKN1B
  • cdkn1bb
  • Cdkn1b
  • cdkn1ba
Alternatives
anti-Human CDKN1B antibody for Immunohistochemistry (Frozen Sections)
Epitope
pSer83
79
58
46
38
29
26
25
20
19
19
19
18
17
16
14
13
10
7
7
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6
4
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4
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3
3
3
3
2
2
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2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human
776
425
362
181
40
24
19
8
8
7
3
3
2
1
1
Host
Rabbit
471
302
39
2
2
1
Clonality (Clone)
Polyclonal ()
Conjugate
This CDKN1B antibody is un-conjugated
40
35
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34
33
29
9
7
7
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5
5
5
5
5
5
5
5
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4
4
4
4
4
4
4
4
4
2
2
2
2
2
1
1
1
1
1
1
1
Application
Dot Blot (DB)
624
337
241
231
196
195
100
91
84
54
37
17
13
5
5
3
1
1
1
Options
Supplier
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Supplier Product No.
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Immunogen This p27Kip1 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S83 of human p27Kip1.
Clone RB42101
Purification This antibody is purified through a protein A column, followed by peptide affinity purification. Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Plasmids, Primers & others Plasmids, Primers & others CDKN1B products on genomics-online (e.g. as negative or positive controls)
Antigen
Alternative Name p27Kip1 (CDKN1B Antibody Abstract)
Background This gene encodes a cyclin-dependent kinase inhibitor, which shares a limited similarity with CDK inhibitor CDKN1A/p21. The encoded protein binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle progression at G1. The degradation of this protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state. [provided by RefSeq].

Synonyms: CDKN1B, KIP1, Cyclin-dependent kinase inhibitor 1B, Cyclin-dependent kinase inhibitor p27, p27Kip1
NCBI Accession NP_004055
UniProt P46527
Pathways Cell Division Cycle, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Positive Regulation of Peptide Hormone Secretion, Negative Regulation of Hormone Secretion, Sensory Perception of Sound, Mitotic G1-G1/S Phases, DNA Replication, Positive Regulation of Endopeptidase Activity, Synthesis of DNA, Autophagy
Application Notes DB: 1:500
Restrictions For Research Use only
Format Liquid
Concentration 0.27 mg/mL
Buffer Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
Preservative Sodium azide
Precaution of Use WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.
Supplier Images
Dot Blot (DB) image for anti-Cyclin-Dependent Kinase Inhibitor 1B (p27, Kip1) (CDKN1B) (pSer83) antibody (ABIN1881622) Dot blot analysis of p27Kip1 Antibody (Phospho S83) Phospho-specific Pab (ABIN1881622...
Product cited in: Kajihara, Fukushige, Shioda, Tanabe, Fukunaga, Inui: "CaMKII phosphorylates serine 10 of p27 and confers apoptosis resistance to HeLa cells." in: Biochemical and biophysical research communications, Vol. 401, Issue 3, pp. 350-5, 2010 (PubMed).

Kedde, van Kouwenhove, Zwart, Oude Vrielink, Elkon, Agami: "A Pumilio-induced RNA structure switch in p27-3' UTR controls miR-221 and miR-222 accessibility." in: Nature cell biology, Vol. 12, Issue 10, pp. 1014-20, 2010 (PubMed).

Canbay, Eraltan, Cercel, Isbir, Gazioglu, Aydogan, Cacina, Cengiz, Ferahman, Zengin, Unal: "CCND1 and CDKN1B polymorphisms and risk of breast cancer." in: Anticancer research, Vol. 30, Issue 7, pp. 3093-8, 2010 (PubMed).

Do Nascimento Borges, Burbano, Harada: "Absence of CIP1/KIP1 hypermethylation in gastric cancer patients from Northern Brazil." in: In vivo (Athens, Greece), Vol. 24, Issue 4, pp. 579-82, 2010 (PubMed).

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