Progesterone Receptor antibody (PGR) (AA 833-861)

Details for Product anti-PGR Antibody No. ABIN1881650, Supplier: Log in to see
Antigen
  • NR3C3
  • PR
  • 9930019P03Rik
  • BB114106
  • ENSMUSG00000074510
  • PR-A
  • PR-B
  • XPR-1
  • pgr
  • xpr-2
  • LOC443444
  • PGR
  • pg
  • pr
  • gb:dq017620
  • progesterone receptor
  • progesterone receptor L homeolog
  • PGR
  • Pgr
  • pgr.L
  • pgr
Alternatives
anti-Human Progesterone Receptor antibody for Immunohistochemistry (Paraffin-embedded Sections)
Epitope
AA 833-861, C-Term
54
53
41
33
26
19
19
18
16
16
15
15
14
12
11
9
8
8
8
7
5
5
4
4
4
3
3
3
3
3
3
3
3
3
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human
530
93
89
20
11
11
9
6
6
5
4
4
2
1
1
1
1
1
1
1
Host
Rabbit
321
219
3
1
Clonality (Clone)
Polyclonal ()
Conjugate
This Progesterone Receptor antibody is un-conjugated
17
17
14
9
9
9
2
2
2
2
2
2
2
2
2
2
2
Application
Western Blotting (WB)
412
148
145
130
95
48
42
27
21
9
8
5
3
2
2
1
1
1
Options
Supplier
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Supplier Product No.
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Immunogen This PGR antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 833-861 amino acids from the C-terminal region of human PGR.
Clone RB41475
Predicted Reactivity Mouse (Murine),Rat (Rattus),Rabbit
Purification This antibody is purified through a protein A column, followed by peptide affinity purification. Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Alternative Name PGR (PGR Antibody Abstract)
Background This gene encodes a member of the steroid receptor superfamily. The encoded protein mediates the physiological effects of progesterone, which plays a central role in reproductive events associated with the establishment and maintenance of pregnancy. This gene uses two distinct promotors and translation start sites in the first exon to produce two isoforms, A and B. The two isoforms are identical except for the additional 165 amino acids found in the N-terminus of isoform B and mediate their own response genes and physiologic effects with little overlap. The location of transcription initiation for isoform A has not been clearly determined.

Synonyms: PGR, NR3C3, Progesterone receptor, Nuclear receptor subfamily 3 group C member 3
NCBI Accession NP_001189403, NP_001258091, NP_000917
UniProt P06401
Pathways Nuclear Receptor Transcription Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Steroid Hormone Mediated Signaling Pathway, Smooth Muscle Cell Migration
Application Notes WB: 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
Preservative Sodium azide
Precaution of Use WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.
Supplier Images
Western Blotting (WB) image for anti-Progesterone Receptor (PGR) (AA 833-861), (C-Term) antibody (ABIN1881650) PGR Antibody (C-term) (ABIN1881650) western blot analysis in ZR-75-1 cell line lysate...
Product cited in: Van Belle, Van Calster, Brouckaert, Vanden Bempt, Pintens, Harvey, Murray, Naume, Wiedswang, Paridaens, Moerman, Amant, Leunen, Smeets, Drijkoningen, Wildiers, Christiaens, Vergote, Van Huffel, Neven: "Qualitative assessment of the progesterone receptor and HER2 improves the Nottingham Prognostic Index up to 5 years after breast cancer diagnosis." in: Journal of clinical oncology : official journal of the American Society of Clinical Oncology, Vol. 28, Issue 27, pp. 4129-34, 2010 (PubMed).

Geradts, Bean, Bentley, Barry: "The oncotype DX recurrence score is correlated with a composite index including routinely reported pathobiologic features." in: Cancer investigation, Vol. 28, Issue 9, pp. 969-77, 2010 (PubMed).

Tang, Wang, Hicks, Wang, Schiffhauer, McMahon, Yang, Shayne, Huston, Skinner, Griggs, Lyman: "A lower Allred score for progesterone receptor is strongly associated with a higher recurrence score of 21-gene assay in breast cancer." in: Cancer investigation, Vol. 28, Issue 9, pp. 978-82, 2010 (PubMed).

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