PSMC1 antibody (C-Term)

Catalog No. ABIN1881692

There are 3+ publications for this product available. The Rabbit Polyclonal anti-PSMC1 antibody is suitable to detect PSMC1 in samples from Human, Mouse and Rat. It has been validated for WB, IHC (p) and IF.

Quick Overview for PSMC1 antibody (C-Term) (ABIN1881692)

Target: PSMC1 (Proteasome (Prosome, Macropain) 26S Subunit, ATPase, 1 (PSMC1))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PSMC1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)

Clone: RB44417

Product Details anti-PSMC1 Antibody

Binding Specificity: AA 408-436, C-Term

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This PRS4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 408-436 amino acids from the C-terminal region of human PRS4.

Isotype: Ig Fraction

Application Details

Application Notes: IF: 1:25. WB: 1:1000. IHC-P: 1:25

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

References for anti-PSMC1 antibody (ABIN1881692)

Katiyar, Li, Lennarz: "A complex between peptide:N-glycanase and two proteasome-linked proteins suggests a mechanism for the degradation of misfolded glycoproteins." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 101, Issue 38, pp. 13774-9, (2004) (PubMed).

Matilla, Gorbea, Einum, Townsend, Michalik, van Broeckhoven, Jensen, Murphy, Ptácek, Fu: "Association of ataxin-7 with the proteasome subunit S4 of the 19S regulatory complex." in: Human molecular genetics, Vol. 10, Issue 24, pp. 2821-31, (2001) (PubMed).

Dubiel, Ferrell, Pratt, Rechsteiner: "Subunit 4 of the 26 S protease is a member of a novel eukaryotic ATPase family." in: The Journal of biological chemistry, Vol. 267, Issue 32, pp. 22699-702, (1992) (PubMed).

Target Details for PSMC1

Target: PSMC1 (Proteasome (Prosome, Macropain) 26S Subunit, ATPase, 1 (PSMC1))

Background: The 26S protease is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex.

Molecular Weight: 49185

NCBI Accession: NP_002793

UniProt: P62191

Pathways: Mitotic G1-G1/S Phases, DNA Replication, Synthesis of DNA, Ubiquitin Proteasome Pathway