PSMC1 antibody (AA 77-440)

Catalog No. ABIN7269584

Product Details anti-PSMC1 Antibody

Target: PSMC1 (Proteasome (Prosome, Macropain) 26S Subunit, ATPase, 1 (PSMC1))

Binding Specificity: AA 77-440

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PSMC1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Purpose: PSMC1 Rabbit pAb

Sequence: EFIRNQEQMK PLEEKQEEER SKVDDLRGTP MSVGTLEEII DDNHAIVSTS VGSEHYVSIL SFVDKDLLEP GCSVLLNHKV HAVIGVLMDD TDPLVTVMKV EKAPQETYAD IGGLDNQIQE IKESVELPLT HPEYYEEMGI KPPKGVILYG PPGTGKTLLA KAVANQTSAT FLRVVGSELI QKYLGDGPKL VRELFRVAEE HAPSIVFIDE IDAIGTKRYD SNSGGEREIQ RTMLELLNQL DGFDSRGDVK VIMATNRIET LDPALIRPGR IDRKIEFPLP DEKTKKRIFQ IHTSRMTLAD DVTLDDLIMA KDDLSGADIK AICTEAGLMA LRERRMKVTN EDFKKSKENV LYKKQEGTPE GLYL

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 77-440 of human PSMC1 (NP_002793.2).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IHC,1:100 - 1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for PSMC1

Target: PSMC1 (Proteasome (Prosome, Macropain) 26S Subunit, ATPase, 1 (PSMC1))

Alternative Name: PSMC1 (PSMC1 Products)

Synonyms: AI325227 antibody, P26s4 antibody, S4 antibody, P26S4 antibody, p56 antibody, s4 antibody, protease (prosome, macropain) 26S subunit, ATPase 1 antibody, proteasome 26S subunit, ATPase 1 antibody, Psmc1 antibody, PSMC1 antibody

Background: The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits, 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases which have a chaperone-like activity. This subunit and a 20S core alpha subunit interact specifically with the hepatitis B virus X protein, a protein critical to viral replication. This subunit also interacts with the adenovirus E1A protein and this interaction alters the activity of the proteasome. Finally, this subunit interacts with ataxin-7, suggesting a role for the proteasome in the development of spinocerebellar ataxia type 7, a progressive neurodegenerative disorder.,PSMC1,P26S4,S4,p56,ATPase 1,Epigenetics & Nuclear Signaling,RNA Binding,Cell Biology & Developmental Biology,Ubiquitin,PSMC1

Molecular Weight: 41kDa/49kDa

Gene ID: 5700

UniProt: P62191

Pathways: Mitotic G1-G1/S Phases, DNA Replication, Synthesis of DNA, Ubiquitin Proteasome Pathway