TFAP2A antibody (N-Term)

Catalog No. ABIN1882156

This Rabbit Polyclonal antibody specifically detects TFAP2A in WB. It exhibits reactivity toward Human. It has been mentioned in 3+ publications

Quick Overview for TFAP2A antibody (N-Term) (ABIN1882156)

Target: TFAP2A (Transcription Factor AP-2 alpha (Activating Enhancer Binding Protein 2 Alpha) (TFAP2A))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TFAP2A antibody is un-conjugated

Application: Western Blotting (WB)

Clone: RB12671

Product Details anti-TFAP2A Antibody

Binding Specificity: AA 104-133, N-Term

Predicted Reactivity: B, M, Rat, Sh

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This AP2 alpha antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 104-133 amino acids from the N-terminal region of human AP2 alpha.

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

References for anti-TFAP2A antibody (ABIN1882156)

Semenza: "Oxygen-dependent regulation of mitochondrial respiration by hypoxia-inducible factor 1." in: The Biochemical journal, Vol. 405, Issue 1, pp. 1-9, (2007) (PubMed).

Provenzano, Yu, Hitchler, Fitzgerald, Robinson, Wayne, Ver Meer, Domann: "AP-2 participates in the transcriptional control of the amyloid precursor protein (APP) gene in oral squamous cell carcinoma." in: Experimental and molecular pathology, Vol. 83, Issue 2, pp. 277-82, (2007) (PubMed).

Han, Ritzenthaler, Wingerd, Rivera, Roman: "Extracellular matrix fibronectin increases prostaglandin E2 receptor subtype EP4 in lung carcinoma cells through multiple signaling pathways: the role of AP-2." in: The Journal of biological chemistry, Vol. 282, Issue 11, pp. 7961-72, (2007) (PubMed).

Target Details for TFAP2A

Target: TFAP2A (Transcription Factor AP-2 alpha (Activating Enhancer Binding Protein 2 Alpha) (TFAP2A))

Alternative Name: AP2 alpha

Background: Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limbs and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2 alpha is the only AP-2 protein required for early morphogenesis of the lens vesicle.

Molecular Weight: 48062

NCBI Accession: NP_001027451, NP_001035890, NP_003211

UniProt: P05549

Pathways: Caspase Cascade in Apoptosis, EGFR Signaling Pathway, Response to Water Deprivation, Sensory Perception of Sound, Tube Formation, Embryonic Body Morphogenesis, Brown Fat Cell Differentiation, Lipid Metabolism