Germ Cell Associated 2 (Haspin) (GSG2) (AA 323-352), (Center) antibody

Details for Product No. ABIN1882168, Supplier: Log in to see
Antigen
  • BcDNA:LD07633
  • CG40080
  • Dmel\\CG40080
  • haspin
  • NV16901
  • HASPIN
  • Haspin
  • putative serine/threonine-protein kinase haspin homolog
  • histone H3 associated protein kinase
  • CG40080 gene product from transcript CG40080-RA
  • uncharacterized LOC100122327
  • LOC552287
  • HASPIN
  • Haspin
  • LOC100122327
Epitope
AA 323-352, Center
15
7
3
3
2
2
1
1
1
Reactivity
Human
50
15
15
2
2
Host
Rabbit
47
5
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
3
3
3
2
2
2
1
1
1
1
1
1
1
1
1
1
1
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
22
22
15
13
8
4
2
2
2
Options
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Immunogen This Haspin GSG2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 323~352 amino acids from the central region of human haspin.
Clone RB3404
Purification This antibody is purified through a protein A column, followed by peptide affinity purification. Purified Rabbit Polyclonal Antibody (Pab)
Antigen
Alternative Name Haspin GSG2 (GSG2 Antibody Abstract)
Background Post-translational modifications of conserved N-terminal tail residues in histones regulate many aspects of chromosome activity. Mitotic phosphorylation of H3 Thr 3 occurs in prophase and dephosphorylation during anaphase. Haspin, a dual serine/threonine kinase, plays an important role in regulation of chromosome and spindle function during mitosis and meiosis via its function in phosphorylation of the threonine residue in the third position of histone 3 (Thr3).

Synonyms: Serine/threonine-protein kinase Haspin, Haploid germ cell-specific nuclear protein kinase, H-Haspin, Germ cell-specific gene 2 protein, GSG2
NCBI Accession NP_114171
UniProt Q8TF76
Application Notes WB: 1:1000,IHC (p): 1:50-100
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
Preservative Sodium azide
Precaution of Use WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.
Supplier Images
Immunohistochemistry (IHC) image for anti-Germ Cell Associated 2 (Haspin) (GSG2) (AA 323-352), (Center) antibody (ABIN1882168) Haspin Antibody (R330) (ABIN1882168) western blot analysis in Daudi,Raji cell line ly...
Western Blotting (WB) image for anti-Germ Cell Associated 2 (Haspin) (GSG2) (AA 323-352), (Center) antibody (ABIN1882168) Haspin Antibody (R330) (ABIN1882168) western blot analysis in Daudi,Raji cell line ly...
Western Blotting (WB) image for anti-Germ Cell Associated 2 (Haspin) (GSG2) (AA 323-352), (Center) antibody (ABIN1882168) All lanes : Anti-GSG2 Antibody (Center) at 1:1000 dilution Lane 1: human testis lysat...
Product cited in: Dai, Sultan, Taylor, Higgins: "The kinase haspin is required for mitotic histone H3 Thr 3 phosphorylation and normal metaphase chromosome alignment." in: Genes & development, Vol. 19, Issue 4, pp. 472-88, 2005 (PubMed).

Higgins: "The Haspin gene: location in an intron of the integrin alphaE gene, associated transcription of an integrin alphaE-derived RNA and expression in diploid as well as haploid cells." in: Gene, Vol. 267, Issue 1, pp. 55-69, 2001 (PubMed).

Tanaka, Iguchi, Nakamura, Kohroki, de Carvalho, Nishimune: "Cloning and characterization of human haspin gene encoding haploid germ cell-specific nuclear protein kinase." in: Molecular human reproduction, Vol. 7, Issue 3, pp. 211-8, 2001 (PubMed).

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