COMT antibody (N-Term)

Catalog No. ABIN1882224

Cited in 5+ publications. The Mouse Monoclonal anti-COMT antibody (Clone 630CT1-7-1) (ABIN1882224) specifically detects COMT in WB. The antibody is reactive with Human samples.

Quick Overview for COMT antibody (N-Term) (ABIN1882224)

Target: COMT (Catechol-O-Methyltransferase (COMT))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This COMT antibody is un-conjugated

Application: Western Blotting (WB)

Clone: 630CT1-7-1

Product Details anti-COMT Antibody

Binding Specificity: AA 37-65, N-Term

Purification: Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide.

Immunogen: This COMT antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 37-65 amino acids from the N-terminal region of human COMT.

Isotype: IgG1

Application Details

Application Notes: WB: 1:100~400

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Mouse monoclonal antibody supplied in crude ascites with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

References for anti-COMT antibody (ABIN1882224)

Zeng, Ye, Lu, Chua, Tan, Zhong: "Chiral Brønsted acid catalyzed enantioselective addition of alpha-isocyanoacetamides to aldehydes." in: Organic letters, Vol. 12, Issue 10, pp. 2414-7, (2010) (PubMed).

Stroth, Reinhardt, Thöne, Hille, Schneider, Härtel, Weidemann, Bös, Spitzer: "Impact of aerobic exercise training on cognitive functions and affect associated to the COMT polymorphism in young adults." in: Neurobiology of learning and memory, Vol. 94, Issue 3, pp. 364-72, (2010) (PubMed).

Lim, Kim, Kim, Park, Han, Han, Lee, Yang, Ryu: "Genetic polymorphism of catechol-O-methyltransferase and cytochrome P450c17α in preeclampsia." in: Pharmacogenetics and genomics, Vol. 20, Issue 10, pp. 605-10, (2010) (PubMed).

Demetrovics, Varga, Szekely, Vereczkei, Csorba, Balazs, Hoffman, Sasvari-Szekely, Barta: "Association between Novelty Seeking of opiate-dependent patients and the catechol-O-methyltransferase Val(158)Met polymorphism." in: Comprehensive psychiatry, Vol. 51, Issue 5, pp. 510-5, (2010) (PubMed).

Bodenmann, Landolt: "Effects of modafinil on the sleep EEG depend on Val158Met genotype of COMT." in: Sleep, Vol. 33, Issue 8, pp. 1027-35, (2010) (PubMed).

Target Details for COMT

Target: COMT (Catechol-O-Methyltransferase (COMT))

Alternative Name: COMT

Background: Catechol-O-methyltransferase catalyzes the transfer of a methyl group from S-adenosylmethionine to catecholamines, including the neurotransmitters dopamine, epinephrine, and norepinephrine. This O-methylation results in one of the major degradative pathways of the catecholamine transmitters. In addition to its role in the metabolism of endogenous substances, COMT is important in the metabolism of catechol drugs used in the treatment of hypertension, asthma, and Parkinson disease. COMT is found in two forms in tissues, a soluble form (S-COMT) and a membrane-bound form (MB-COMT). The differences between S-COMT and MB-COMT reside within the N-termini. Several transcript variants are formed through the use of alternative translation initiation sites and promoters.

Molecular Weight: 30037

NCBI Accession: NP_000745, NP_001128633, NP_001128634, NP_009294

UniProt: P21964

Pathways: Steroid Hormone Biosynthesis, SARS-CoV-2 Protein Interactome