TS (AA 122-306) antibody
Reactivity: Human
WB
Host: Rabbit
Polyclonal
unconjugated
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- Target
- TS
- Binding Specificity
- AA 122-306
- Reactivity
- Human
- Host
- Rabbit
- Clonality
- Polyclonal
- Application
- Western Blotting (WB)
- Purification
- Purified by antigen-affinity chromatography.
- Immunogen
- Recombinant protein fragment contain a sequence corresponding to a region within amino acids 122 and 306 of human TYMS
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- Application Notes
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Suggested dilutions:
Western blotting: 1.500-1.3000 - Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- 0.1 M Tris-buffered saline with 10 % Glycerol (pH 7.0).0.01 % Thimerosal was added as a preservative.
- Preservative
- Thimerosal (Merthiolate)
- Precaution of Use
- Biohazard Informations: This product contains thimerosal which is hazardous.
- Storage
- 4 °C/-20 °C
- Storage Comment
- Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.
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- Target
- TS
- Background
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Thymidylate synthase catalyzes the methylation of deoxyuridylate to deoxythymidylate using 5,10-methylenetetrahydrofolate (methylene-THF) as a cofactor.This function maintains the dTMP (thymidine-5-prime monophosphate) pool critical for DNA replication and repair.The enzyme has been of interest as a target for cancer chemotherapeutic agents.It is considered to be the primary site of action for 5-fluorouracil, 5-fluoro-2-prime-deoxyuridine, and some folate analogs.Expression of this gene and that of a naturally occuring antisense transcript rTSalpha (GeneID:55556) vary inversely when cell-growth progresses from late-log to plateau phase.[provided by RefSeq]
- Molecular Weight
- 36 kDa
- Gene ID
- 7298
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