LBP antibody (AA 166-437)

Catalog No. ABIN1886097

The Rabbit Polyclonal anti-LBP antibody (ABIN1886097) specifically detects LBP in WB and IHC. The antibody is reactive with Human samples.

Quick Overview for LBP antibody (AA 166-437) (ABIN1886097)

Target: LBP (Lipopolysaccharide Binding Protein (LBP))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This LBP antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-LBP Antibody

Binding Specificity: AA 166-437

Purification: Purified by antigen-affinity chromatography.

Immunogen: Recombinant protein fragment contain a sequence corresponding to a region within amino acids 166 and 437 of Human LBP

Application Details

Application Notes: Suggested dilutions:
Western blotting: 1.500-1.3000
Immunohistochemistry: 1.100-1.250

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: 0.1 M Tris-buffered saline with 10 % Glycerol (pH 7.0).0.01 % Thimerosal was added as a preservative.

Preservative: Thimerosal (Merthiolate)

Precaution of Use: Biohazard Informations: This product contains thimerosal which is hazardous.

Storage: 4 °C/-20 °C

Storage Comment: Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.

Target Details for LBP

Target: LBP (Lipopolysaccharide Binding Protein (LBP))

Alternative Name: LBP

Background: The protein encoded by this gene is involved in the acute-phase immunologic response to gram-negative bacterial infections.Gram-negative bacteria contain a glycolipid, lipopolysaccharide (LPS), on their outer cell wall.Together with bactericidal permeability-increasing protein (BPI), the encoded protein binds LPS and interacts with the CD14 receptor, probably playing a role in regulating LPS-dependent monocyte responses.Studies in mice suggest that the encoded protein is necessary for the rapid acute-phase response to LPS but not for the clearance of LPS from circulation.This protein is part of a family of structurally and functionally related proteins, including BPI, plasma cholesteryl ester transfer protein (CETP), and phospholipid transfer protein (PLTP).Finally, this gene is found on chromosome 20, immediately downstream of the BPI gene.[provided by RefSeq]

Molecular Weight: 53 kDa

Gene ID: 3929

NCBI Accession: NP_004130, NM_004139

Pathways: TLR Signaling, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Positive Regulation of Immune Effector Process, Toll-Like Receptors Cascades, Monocarboxylic Acid Catabolic Process