Retinoblastoma Binding Protein 8 antibody (AA 452-747)

Catalog No. ABIN1886481

The Rabbit Polyclonal anti-Retinoblastoma Binding Protein 8 antibody (ABIN1886481) specifically detects Retinoblastoma Binding Protein 8 in WB. The antibody is reactive with Human samples.

Quick Overview for Retinoblastoma Binding Protein 8 antibody (AA 452-747) (ABIN1886481)

Target: Retinoblastoma Binding Protein 8 (RBBP8)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Retinoblastoma Binding Protein 8 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-Retinoblastoma Binding Protein 8 Antibody

Binding Specificity: AA 452-747

Purification: Purified by antigen-affinity chromatography.

Immunogen: Recombinant protein fragment contain a sequence corresponding to a region within amino acids 452 and 747 of CtIP

Application Details

Application Notes: Suggested dilutions:
Western blotting: 1.500-1.3000
Immunohistochemistry: 1.100-1.500

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: 0.1 M Tris-buffered saline with 10 % Glycerol (pH 7.0).0.01 % Thimerosal was added as a preservative.

Preservative: Thimerosal (Merthiolate)

Precaution of Use: Biohazard Informations: This product contains thimerosal which is hazardous.

Storage: 4 °C/-20 °C

Storage Comment: Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.

Target Details for Retinoblastoma Binding Protein 8

Target: Retinoblastoma Binding Protein 8 (RBBP8)

Alternative Name: CtIP

Background: The protein encoded by this gene is a ubiquitously expressed nuclear protein.It is found among several proteins that bind directly to retinoblastoma protein, which regulates cell proliferation.This protein complexes with transcriptional co-repressor CTBP.It is also associated with BRCA1 and is thought to modulate the functions of BRCA1 in transcriptional regulation, DNA repair, and/or cell cycle checkpoint control.It is suggested that this gene may itself be a tumor suppressor acting in the same pathway as BRCA1.Three transcript variants encoding two different isoforms have been found for this gene.More transcript variants exist, but their full-length natures have not been determined.[provided by RefSeq]

Molecular Weight: 102 kDa

Gene ID: 5932

NCBI Accession: NM_002894, NP_002885

Pathways: Cell Division Cycle, DNA Damage Repair