HLA-DRB1 antibody (AA 56-260)

Catalog No. ABIN1886555

The Rabbit Polyclonal anti-HLA-DRB1 antibody is suitable to detect HLA-DRB1 in samples from Human. It has been validated for WB.

Quick Overview for HLA-DRB1 antibody (AA 56-260) (ABIN1886555)

Target: HLA-DRB1 (Major Histocompatibility Complex, Class II, DR beta 1 (HLA-DRB1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HLA-DRB1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-HLA-DRB1 Antibody

Binding Specificity: AA 56-260

Purification: Purified by antigen-affinity chromatography.

Immunogen: Recombinant protein fragment contain a sequence corresponding to a region within amino acids 56 and 260 of Human HLA-DRB1

Application Details

Application Notes: Suggested dilutions:
Western blotting: 1.500-1.3000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: 0.1 M Tris-buffered saline with 20 % Glycerol (pH 7.0).0.01 % Thimerosal was added as a preservative.

Preservative: Thimerosal (Merthiolate)

Precaution of Use: Biohazard Informations: This product contains thimerosal which is hazardous.

Storage: 4 °C/-20 °C

Storage Comment: Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.

Target Details for HLA-DRB1

Target: HLA-DRB1 (Major Histocompatibility Complex, Class II, DR beta 1 (HLA-DRB1))

Alternative Name: HLA-DRB1

Background: HLA-DRB1 belongs to the HLA class II beta chain paralogs.The class II molecule is a heterodimer consisting of an alpha (DRA) and a beta chain (DRB), both anchored in the membrane.It plays a central role in the immune system by presenting peptides derived from extracellular proteins.Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages).The beta chain is approximately 26-28 kDa.It is encoded by 6 exons.Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain, and exon 5 encodes the cytoplasmic tail.Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities.Hundreds of DRB1 alleles have been described and typing for these polymorphisms is routinely done for bone marrow and kidney transplantation.DRB1 is expressed at a level five times higher than its paralogs DRB3, DRB4 and DRB5.DRB1 is present in all individuals.Allelic variants of DRB1 are linked with either none or one of the genes DRB3, DRB4 and DRB5.There are 4 related pseudogenes: DRB2, DRB6, DRB7, DRB8 and DRB9.[provided by RefSeq]

Molecular Weight: 30 kDa

Gene ID: 3123

Pathways: TCR Signaling, Positive Regulation of Peptide Hormone Secretion, Production of Molecular Mediator of Immune Response, CXCR4-mediated Signaling Events, Cancer Immune Checkpoints, Human Leukocyte Antigen (HLA) in Adaptive Immune Response