VAV1 antibody (AA 83-538)

Catalog No. ABIN1886679

The Rabbit Polyclonal anti-VAV1 antibody (ABIN1886679) specifically detects VAV1 in WB and IHC. The antibody is reactive with Human samples.

Quick Overview for VAV1 antibody (AA 83-538) (ABIN1886679)

Target: VAV1 (Vav 1 Oncogene (VAV1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This VAV1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-VAV1 Antibody

Binding Specificity: AA 83-538

Purification: Purified by antigen-affinity chromatography.

Immunogen: Recombinant protein fragment contain a sequence corresponding to a region within amino acids 83 and 538 of Human VAV1

Application Details

Application Notes: Suggested dilutions:
Western blotting: 1.500-1.3000
Immunohistochemistry: 1.100-1.250

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: 0.1 M Tris-buffered saline with 10 % Glycerol (pH 7.0).0.01 % Thimerosal was added as a preservative.

Preservative: Thimerosal (Merthiolate)

Precaution of Use: Biohazard Informations: This product contains thimerosal which is hazardous.

Storage: 4 °C/-20 °C

Storage Comment: Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.

Target Details for VAV1

Target: VAV1 (Vav 1 Oncogene (VAV1))

Alternative Name: VAV1

Background: The protein encoded by this proto-oncogene is a member of the Dbl family of guanine nucleotide exchange factors (GEF) for the Rho family of GTP binding proteins.The protein is important in hematopoiesis, playing a role in T-cell and B-cell development and activation.This particular GEF has been identified as the specific binding partner of Nef proteins from HIV-1.Coexpression and binding of these partners initiates profound morphological changes, cytoskeletal rearrangements and the JNK/SAPK signaling cascade, leading to increased levels of viral transcription and replication.[provided by RefSeq]
Synonyms: VAV

Molecular Weight: 98 kDa

Gene ID: 7409

NCBI Accession: NM_005428, NP_005419

Pathways: TCR Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, CXCR4-mediated Signaling Events, BCR Signaling