Perforin 1 antibody (AA 9-184)

Catalog No. ABIN1886703

The Rabbit Polyclonal anti-Perforin 1 antibody (ABIN1886703) specifically detects Perforin 1 in WB. The antibody is reactive with Human samples.

Quick Overview for Perforin 1 antibody (AA 9-184) (ABIN1886703)

Target: Perforin 1 (PRF1) (Perforin 1 (Pore Forming Protein) (PRF1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Perforin 1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-Perforin 1 Antibody

Binding Specificity: AA 9-184

Purification: Purified by antigen-affinity chromatography.

Immunogen: Recombinant protein fragment contain a sequence corresponding to a region within amino acids 9 and 184 of Perforin 1

Application Details

Application Notes: Suggested dilutions:
Western blotting: 1.500-1.3000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: 0.1 M Tris-buffered saline with 10 % Glycerol (pH 7.0).0.01 % Thimerosal was added as a preservative.

Preservative: Thimerosal (Merthiolate)

Precaution of Use: Biohazard Informations: This product contains thimerosal which is hazardous.

Storage: 4 °C/-20 °C

Storage Comment: Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.

Target Details for Perforin 1

Target: Perforin 1 (PRF1) (Perforin 1 (Pore Forming Protein) (PRF1))

Alternative Name: Perforin 1

Background: The protein encoded by this gene has structural and functional similarities to complement component 9 (C9).Like C9, this protein creates transmembrane tubules and is capable of lysing non-specifically a variety of target cells.This protein is one of the main cytolytic proteins of cytolytic granules, and it is known to be a key effector molecule for T-cell- and natural killer-cell-mediated cytolysis.Defects in this gene cause familial hemophagocytic lymphohistiocytosis type 2 (HPLH2), a rare and lethal autosomal recessive disorder of early childhood.Alternative splicing results in multiple transcript variants encoding the same protein.[provided by RefSeq]
Synonyms: HPLH2, MGC65093, P1, PFP

Molecular Weight: 61 kDa

Gene ID: 5551

NCBI Accession: NM_005041, NP_005032

Pathways: Apoptosis, Caspase Cascade in Apoptosis