Caspase 9 antibody (AA 299-318)

Catalog No. ABIN1886865

This anti-Caspase 9 antibody is a Rabbit Polyclonal antibody detecting Caspase 9 in WB, ELISA and ICC. Suitable for Human. This Primary Antibody has been cited in 1 publication.

Quick Overview for Caspase 9 antibody (AA 299-318) (ABIN1886865)

Target: Caspase 9 (CASP9) (Caspase 9, Apoptosis-Related Cysteine Peptidase (CASP9))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Caspase 9 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunocytochemistry (ICC)

Product Details anti-Caspase 9 Antibody

Binding Specificity: AA 299-318

Cross-Reactivity (Details): It has no cross response to other members in caspase family.

Purification: Affinity chromatography purified via peptide column

Immunogen: Peptide corresponding to amino acids 299 to 318 of human caspase-9.

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Handling Advice: Avoid freezing and thawing repeatly.

Storage: 4 °C/-20 °C

Storage Comment: Store at 4 °C for short term use.Store at -20 °C for long term preservation.

References for anti-Caspase 9 antibody (ABIN1886865)

Zhang, Yi, Liu, Zhao, Chen: "Quercetin induces apoptosis via the mitochondrial pathway in KB and KBv200 cells." in: Journal of agricultural and food chemistry, Vol. 61, Issue 9, pp. 2188-95, (2013) (PubMed).

Target Details for Caspase 9

Target: Caspase 9 (CASP9) (Caspase 9, Apoptosis-Related Cysteine Peptidase (CASP9))

Alternative Name: Caspase-9

Background: Apoptosis is related to many diseases and induced by a family of cell death receptors and their ligands.Cell death signals are transduced by death domain containing adapter molecules and members of the caspase family of proteases.A novel member in the caspase family was recently identified and designated ICE-LAP6, Mch6, and Apaf-3.Caspase-9 and Apaf-1 bind to each other, which leads to caspase-9 activation.Caspase-9 is also activated by granzyme B and CPP32.Activated caspase-9 cleaves and activates caspase-3 that is one of the key proteases, being responsible for the proteolytic cleavage of many key proteins in apoptosis.Caspase-9 play a central role in cell death induced by a wide variety of apoptosis activators including TNFalpha, TRAIL, anti-CD-95, FADD, and TRADD.Caspase-9 is expressed in a variety of human tissues.
Synonyms: Mch6, Apaf-3, Casp-9

Molecular Weight: 46 kDa

UniProt: P55211

Pathways: MAPK Signaling, RTK Signaling, Apoptosis, Caspase Cascade in Apoptosis, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Positive Regulation of Endopeptidase Activity