BICD1 antibody (C-Term)

Catalog No. ABIN1887005

Product Details anti-BICD1 Antibody

Target: BICD1 (Bicaudal D Homolog 1 (BICD1))

Binding Specificity: C-Term

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This BICD1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunocytochemistry (ICC)

Specificity: At least two isoforms of BICD1 are known to exist, this antibody will only recognize the larger isoform.

Purification: Affinity chromatography purified via peptide column

Immunogen: 15 amino acid peptide from near the carboxy terminus of human BICD1.

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Handling Advice: Avoid freezing and thawing repeatly.

Storage: 4 °C/-20 °C

Storage Comment: Store at 4 °C for short term use.Store at -20 °C for long term preservation.

Target Details for BICD1

Target: BICD1 (Bicaudal D Homolog 1 (BICD1))

Alternative Name: BICD1 (BICD1 Products)

Synonyms: BICD antibody, B830009D06Rik antibody, mKIAA4125 antibody, bicaudal D homolog 1 L homeolog antibody, BICD cargo adaptor 1 antibody, bicaudal D homolog 1 (Drosophila) antibody, bicd1.L antibody, BICD1 antibody, Bicd1 antibody

Background: BICD1 was initially identified as the human homolog to Drosophila Bicaudal-D protein that forms part of the cytoskeleton and mediates the correct sorting of mRNAs for oocyte- and axis-determining factors during oogenesis.BICD1 can bind to dynein-dynactin and co-localizes with Rab6A on the trans-Golgi network and cytoplasmic vesicles, suggesting BICD1 regulates COPI-independent Golgi-ER transport.BICD1 will also interact with Rab6B, a Rab6 isoform that is expressed primarily in brain.Live cell imaging showed bi-directional movement of Rab6B structures in SK-N-SH neurites, indicating that BICD1 is involved in the Rab6B regulation of retrograde cargo transport in neuronal cells.
Synonyms: Bicaudal D homolog 1

NCBI Accession: NP_001705

Pathways: Ribonucleoprotein Complex Subunit Organization, Regulation of G-Protein Coupled Receptor Protein Signaling, Maintenance of Protein Location