FRMPD4 antibody (Center)

Catalog No. ABIN1887749

Product Details anti-FRMPD4 Antibody

Target: FRMPD4 (FERM and PDZ Domain Containing 4 (FRMPD4))

Binding Specificity: Center

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FRMPD4 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Purification: Affinity chromatography purified via peptide column

Immunogen: FRMPD4 antibody was raised against an 18 amino acid peptide from near the center of human FRMPD4.

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Handling Advice: Avoid freezing and thawing repeatly.

Storage: 4 °C/-20 °C

Storage Comment: Store at 4 °C for short term use.Store at -20 °C for long term preservation.

Target Details for FRMPD4

Target: FRMPD4 (FERM and PDZ Domain Containing 4 (FRMPD4))

Alternative Name: FRMPD4 (FRMPD4 Products)

Synonyms: RGD1566031 antibody, PDZD10 antibody, PDZK10 antibody, Gm196 antibody, PKAP1 antibody, Pdzd10 antibody, Pdzk10 antibody, Preso1 antibody, FERM and PDZ domain containing 4 antibody, Frmpd4 antibody, FRMPD4 antibody, frmpd4 antibody

Background: The FERM and PDZ domain containing (FRMPD) protein family consists of four proteins that contain a FERM (Four-point-one, erzin, radixin, moesin) domain and at least one PDZ (PSD-95/Discs large/Zonula-occuldens-1) domain.FRMPD4, also known as Preso, also contains another protein interaction domain termed WW (domain with two conserved Trp residues) at its amino terminus.It was identified through a yeast two-hybrid screen using the PDZ domain of PSD-95 as bait and is highly expressed in multiple regions of the brain and is enriched in the postsynaptic density (PSD) fractions.Overexpression of FRMPD4 in cultured hippocampal neurons significantly increased the linear density of dendritic spines without changing their length and width, conversely, knockdown experiments using RNAi caused a decrease in spine density, indicating FRMPD4 positively regulates dendritic spine density but not morphology.The decreased level of FRMPD4 also resulted in reduced levels of excitatory synaptic transmission, suggesting that FRMPD4 is required for maintenance of excitatory synaptic transmission.
Synonyms: FERM and PDZ domain-containing 4, Preso, PDZD10, PDZK10

NCBI Accession: NP_055553