SIPA1L1 antibody (N-Term)

Catalog No. ABIN1887972

Product Details anti-SIPA1L1 Antibody

Target: SIPA1L1 (Signal-Induced Proliferation-Associated 1 Like 1 (SIPA1L1))

Binding Specificity: N-Term

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SIPA1L1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Purification: Affinity chromatography purified via peptide column

Immunogen: 16 amino acid peptide from near the amino terminus of human SIPA1L1.

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Handling Advice: Avoid freezing and thawing repeatly.

Storage: 4 °C/-20 °C

Storage Comment: Store at 4 °C for short term use.Store at -20 °C for long term preservation.

Target Details for SIPA1L1

Target: SIPA1L1 (Signal-Induced Proliferation-Associated 1 Like 1 (SIPA1L1))

Alternative Name: SIPA1L1 (SIPA1L1 Products)

Synonyms: 4931426N11Rik antibody, AW213287 antibody, Spar antibody, mKIAA0440 antibody, SPAL antibody, Spa-1 antibody, Spa1 antibody, E6TP1 antibody, cb600 antibody, id:ibd5092 antibody, sb:cb600 antibody, si:ch211-106p8.1 antibody, wu:fc43g06 antibody, signal induced proliferation associated 1 like 1 antibody, signal-induced proliferation-associated 1 like 1 antibody, SIPA1L1 antibody, sipa1l1 antibody, Sipa1l1 antibody

Background: Signal-induced proliferation associated-like protein 1 (SIPA1L1) is a member of the SIPA1 family of RapGAPs.SIPA1L1 was initially identified as a binding partner and degradation target of the E6 oncoprotein of high-risk papillomaviruses.Recently, it was discovered that Casein kinase I epsilon (CKIe), a Wnt-regulated kinase that regulates Wnt/b-catenin signaling, also can bind to the carboxy-terminus of SIPA1L1.CKIe phosphorylates SIPA1L1, thereby reducing its stability and alleviating its inhibition of Rap1, a protein required for Wnt8/CKIe-mediated gastrulation during embryogenesis, suggesting SIPA1L1 plays important roles in embryo development as well as control of cell proliferation.
Synonyms: Signal-induced proliferation associated-like protein 1, E6TP1

NCBI Accession: NP_056371