FBXL20 antibody (N-Term)

Catalog No. ABIN1888092

Product Details anti-FBXL20 Antibody

Target: FBXL20 (F-Box and Leucine-Rich Repeat Protein 20 (FBXL20))

Binding Specificity: N-Term

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FBXL20 antibody is un-conjugated

Application: ELISA, Western Blotting (WB), Immunohistochemistry (IHC)

Purification: Affinity chromatography purified via peptide column

Immunogen: 18 amino acid peptide near the amino terminus of the human SCRAPPER.

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Handling Advice: Avoid freezing and thawing repeatly.

Storage: 4 °C/-20 °C

Storage Comment: Store at 4 °C for short term use.Store at -20 °C for long term preservation.

Target Details for FBXL20

Target: FBXL20 (F-Box and Leucine-Rich Repeat Protein 20 (FBXL20))

Alternative Name: SCRAPPER (FBXL20 Products)

Synonyms: Fbl2 antibody, Fbl20 antibody, fbl20 antibody, MGC81000 antibody, scrapper antibody, FBL2 antibody, 2610511F20Rik antibody, 4632423N09Rik antibody, AI849362 antibody, AL117906 antibody, C86145 antibody, Scr antibody, mKIAA4147 antibody, FBXL2 antibody, Fbxl2 antibody, F-box and leucine rich repeat protein 20 antibody, F-box and leucine-rich repeat protein 20 L homeolog antibody, F-box and leucine-rich repeat protein 20 antibody, F-box/LRR-repeat protein 20 antibody, putative fbxl20 antibody, F-box and leucine rich repeat protein 2 antibody, FBXL20 antibody, fbxl20.L antibody, LOAG_14232 antibody, LOC100080065 antibody, Smp_097020.1 antibody, FBXL2 antibody, Fbxl20 antibody

Background: Members of the F-box protein family, such as Scrapper, are characterized by an approximately 40-amino acid F-box motif.SCF complexes, formed by SKP1, cullin, and F-box proteins, act as protein-ubiquitin ligases.Scrapper is selectively expressed in the brain, broadly expressed within the mouse CNS and is abundant at presynaptic membrane.Scrapper has orthologs in C.elegans, D.melanogaster, and mammals which suggests that it might function as an important membrane-localized E3 ligase in various species.Scrapper is a major presynaptic E3 ubiquitin ligase that acts through RIM1a via degradation and the ubiquitin-proteasome-system (UPS) pathway to critically regulate synaptic transmission.This identifies protein degradation as a mechanism for holding synaptic communication in check.
Synonyms: F-box, Leucine rich repeat protein 20, FBXL20, FBl2, FBL20

NCBI Accession: NP_116264