GRIA2 antibody (Ser880)

Catalog No. ABIN197559

The Rabbit Polyclonal anti-GRIA2 antibody has been validated for WB. It is suitable to detect GRIA2 in samples from Human and Mouse.

Quick Overview for GRIA2 antibody (Ser880) (ABIN197559)

Target: GRIA2 (Glutamate Receptor, Ionotropic, AMPA 2 (GRIA2))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GRIA2 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-GRIA2 Antibody

Binding Specificity: Ser880

Specificity: Glutamate receptor 2 (Precursor) antibody detects endogenous levels of total Glutamate receptor 2(Precursor) protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: The antiserum was produced against synthesized non-phosphopeptide derived from human Glutamate receptor 2(Precursor) around the phosphorylation site of serine 880 (I-E- SP-V-K).

Application Details

Application Notes: Western Blot: 1: 500approx. 1: 1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: PBS (without Mg2+ and Ca2+), pH 7.4 containing 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: -20 °C

Target Details for GRIA2

Target: GRIA2 (Glutamate Receptor, Ionotropic, AMPA 2 (GRIA2))

Alternative Name: Glutamate Receptor 2 / GLUR2

Background: Glutamate receptors sensitive to AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazolpropionate) are ligand-activated cation channels that mediate the fast component of excitatory postsynaptic currents in neurons of the central nervous system. These channels are assembled from 4 related subunits, GLURA (GRIA1), GLURB (GRIA2), GLURC (GRIA3), GLURD (GRIA4), with the GLURB subunit rendering the channel almost impermeable to Ca(2+).Synonyms: AMPA-selective glutamate receptor 2, AMPA2, GRIA2, GluR-B, GluR-K2, Glutamate receptor ionotropic

Gene ID: 2891

NCBI Accession: NP_000817

UniProt: P42262

Pathways: PI3K-Akt Signaling