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PKC delta antibody (AA 643-647)

PKCd Reactivity: Human, Mouse, Rat WB, IHC (p), IF Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN197565
  • Target See all PKC delta (PKCd) Antibodies
    PKC delta (PKCd) (Protein Kinase C, delta (PKCd))
    Binding Specificity
    • 22
    • 20
    • 19
    • 16
    • 15
    • 15
    • 15
    • 15
    • 11
    • 8
    • 8
    • 6
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 643-647
    Reactivity
    • 208
    • 152
    • 150
    • 8
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    Human, Mouse, Rat
    Host
    • 219
    • 9
    Rabbit
    Clonality
    • 208
    • 20
    Polyclonal
    Conjugate
    • 92
    • 15
    • 13
    • 11
    • 9
    • 9
    • 9
    • 9
    • 9
    • 9
    • 8
    • 6
    • 6
    • 6
    • 6
    • 6
    • 5
    This PKC delta antibody is un-conjugated
    Application
    • 163
    • 91
    • 81
    • 80
    • 49
    • 46
    • 36
    • 23
    • 20
    • 13
    • 5
    • 3
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)
    Specificity
    This antibody detects endogenous levels of total PKC-delta protein.
    Purification
    Immunoaffinity Chromatography using epitope-specific immunogen.
    Immunogen
    Peptide sequence around amino acids 643~647 (R-L-Sp-Y-S) derived from Human PKC- delta
    Top Product
    Discover our top product PKCd Primary Antibody
  • Application Notes
    Western blot: 1/500approx. 1/1000. Immunofluorescence: 1/100approx. 1/200. Immunohistochemistry on Paraffin-Embedded Sections: 1/50approx. 1/100.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Concentration
    1.0 mg/mL
    Buffer
    PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % Sodium Azide and 50 % Glycerol.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freezing and thawing.
    Storage
    -20 °C
    Storage Comment
    Store the antibody (in aliquots) at -20 °C.
  • Target
    PKC delta (PKCd) (Protein Kinase C, delta (PKCd))
    Alternative Name
    PRKCD (PKCd Products)
    Synonyms
    MAY1 antibody, PKCD antibody, nPKC-delta antibody, AI385711 antibody, D14Ertd420e antibody, PKC[d] antibody, PKCdelta antibody, Pkcd antibody, fb09d10 antibody, fv43b11 antibody, prkcd antibody, wu:fb09d10 antibody, wu:fv43b11 antibody, zgc:56558 antibody, PKC-delta antibody, may1 antibody, npkc-delta antibody, pkc-delta2 antibody, pkcd antibody, tpa-1 antibody, protein kinase C delta antibody, protein kinase C, delta antibody, protein kinase C, delta a antibody, protein kinase C delta L homeolog antibody, PRKCD antibody, Prkcd antibody, prkcda antibody, prkcd.L antibody, prkcd antibody
    Background
    Protein Kinase C delta (PKC delta) is a 78 kDa member of the novel group (nPKCs: sensitive to diacylglycerol, phosphatidylserine, and phorbol esters) of the PKC family of serine/threonine kinases that are involved in a wide range of physiological processes including mitogenesis, cell survival and transcriptional regulation. PKC delta is an ubiquitously expressed PKC isozyme that has been implicated in the regulation of multiple cellular processes including cell cycle progression and apoptosis. Autophosphorylation of serine 664 (serine 662 in mouse and rat) contributes to PKC delta activity. Serum dependent phosphorylation of serine 664 is mediated by mTOR pathway, is protected from dephosphorylation by phosphorylated threonine 505 in the activation loop, and is implicated in prolactin signaling.Synonyms: PKC delta, PKC-delta, PKCD, Protein kinase C delta type
    Gene ID
    5580
    NCBI Accession
    NP_006245
    UniProt
    Q05655
    Pathways
    Interferon-gamma Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Thyroid Hormone Synthesis, Regulation of Actin Filament Polymerization, Carbohydrate Homeostasis, Myometrial Relaxation and Contraction, M Phase, G-protein mediated Events, Dicarboxylic Acid Transport, Positive Regulation of Response to DNA Damage Stimulus, Interaction of EGFR with phospholipase C-gamma, Thromboxane A2 Receptor Signaling, Lipid Metabolism
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