TNFRSF1A antibody (Tumor Necrosis Factor Receptor Superfamily, Member 1A)

Details for Product anti-TNFRSF1A Antibody No. ABIN1981872, Supplier: Log in to see
Antigen
  • CD120a
  • FPF
  • MS5
  • TBP1
  • TNF-R
  • TNF-R-I
  • TNF-R55
  • TNFAR
  • TNFR1
  • TNFR1-d2
  • TNFR55
  • TNFR60
  • p55
  • p55-R
  • p60
  • TNF-R1
  • TNF-alphaR1
  • TNFRI
  • TNFRp55
  • TNFalpha-R1
  • Tnfr-2
  • Tnfr1
  • fpf
  • tbp1
  • p55-r
  • tnf-r
  • tnfar
  • tnfr1
  • cd120a
  • tnfr55
  • tnfr60
  • xtnfr1
  • wu:fj65b10
  • zgc:85914
  • TNFR I
  • TNFRSF1A
  • TNFA
  • cTNF
  • TNF receptor superfamily member 1A
  • tumor necrosis factor receptor superfamily, member 1a
  • TNF receptor superfamily member 1A S homeolog
  • tumor necrosis factor
  • TNFRSF1A
  • Tnfrsf1a
  • tnfrsf1a.S
  • tnfrsf1a
  • TNF
Alternatives
anti-Human TNFRSF1A antibody for Flow Cytometry
Reactivity
Human
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128
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1
Host
Mouse
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117
22
17
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14
1
Clonality (Clone)
Monoclonal ()
Conjugate
This TNFRSF1A antibody is un-conjugated
35
29
29
17
12
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1
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Application
Functional Studies (Func), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)), Flow Cytometry (FACS), Immunoprecipitation (IP), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
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Options
Supplier
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Supplier Product No.
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Immunogen Recombinant full length human CD120a
Clone H398
Isotype IgG2a
Specificity The mouse monoclonal antibody H398 recognizes the extracellular domain of CD120a, a 55 kDa receptor for tumor necrosis factor. The antibody blocks biological activity of both natural and recombinant human TNF alpha and TNF beta.
Purification Purified from cell culture supernatant by protein-A affinity chromatography.
Purity > 95 % (by SDS-PAGE)
Plasmids, Primers & others Plasmids, Primers & others TNFRSF1A products on genomics-online (e.g. as negative or positive controls)
Antigen
Alternative Name CD120a (TNFRSF1A Antibody Abstract)
Background CD120a / TNF R1, also known as TNFR55 or TNFRSF1A, is a 55 kDa receptor for tumor necrosis factor alpha and it is expressed in most tissues. By binding its trimeric ligand the CD120a protein forms trimers and the conformation change leads to dissociation of the inhibitory factor SODD from its intracellular death domain and in formation of signaling platform. CD120a can mediate apoptosis, and function as a regulator of inflammation. Germline mutations of the extracellular domains of this receptor were found to be associated with the autosomal dominant periodic fever syndrome. The impaired receptor clearance is thought to be a mechanism of the disease.
Gene ID 7132
Pathways NF-kappaB Signaling, Apoptosis, Caspase Cascade in Apoptosis, Hepatitis C
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Buffer Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Do not freeze. Do not use after expiration date stamped on vial label.
Storage 4 °C
Storage Comment Store at 2-8°C. Do not freeze. Do not use after expiration date stamped on vial label.
Product cited in: Baker, Pettitt, Slupsky, Chen, Glenn, Zuzel, Cawley: "Response of hairy cells to IFN-alpha involves induction of apoptosis through autocrine TNF-alpha and protection by adhesion." in: Blood, Vol. 100, Issue 2, pp. 647-53, 2002 (PubMed).

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