Caspase 1 antibody (AA 225-242)

Catalog No. ABIN200369

Product Details anti-Caspase 1 Antibody

Target: Caspase 1 (CASP1)

Binding Specificity: AA 225-242

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Caspase 1 antibody is un-conjugated

Application: Western Blotting (WB), Immunoprecipitation (IP), Immunocytochemistry (ICC)

Specificity: Recognizes human, mouse and rat caspase-1. Detects bands of ~45kD (procaspase-1) and ~20kD (cleavage product) by Western blot.

Purification: Immunoaffinity purified

Immunogen: Synthetic peptide corresponding to aa 225-242 (KTSDSTFLVFMSHGIREG) of human caspase-1.

Type of Immunogen: Synthetic peptide

Application Details

Application Notes: Approved: ICC (10 - 20 μg/mL), IP (4 - 8 μg/mL), WB (0.5 - 4 μg/mL)

Usage: Suitable for use in Western Blot, Immunoprecipitation and Immunocytochemistry. Western Blot: 0.5-4 μg/mL. Immunocytochemistry:10-20 μg/mL. Immunoprecipitation: 4-8 μg/mL.

Comment:

Target Species of Antibody: Human

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: PBS,  pH 7.2, 0.5 % BSA, 0.01 % thimerosal, 30 % glycerol

Preservative: Thimerosal (Merthiolate)

Precaution of Use: This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C,-20 °C

Storage Comment: 4°C or -20°C, Avoid freeze-thaw cycles.

Target Details for Caspase 1

Target: Caspase 1 (CASP1)

Alternative Name: CASP1 / Caspase 1 (CASP1 Products)

Synonyms: ICE antibody, IL1BC antibody, P45 antibody, Il1bc antibody, Ice antibody, CASP1 antibody, CG5370 antibody, DCP-1 antibody, DCP1 antibody, Dcp1 antibody, Dmel\\CG5370 antibody, ccp1 antibody, dcp-1 antibody, dcp1 antibody, l(2)01862 antibody, l(2)02132 antibody, caspase 1 antibody, caspase 1, apoptosis-related cysteine peptidase antibody, caspase 4, apoptosis-related cysteine peptidase antibody, Death caspase-1 antibody, caspase-1 antibody, caspase antibody, caspase recruitment domain-containing protein 16 antibody, caspase 4 antibody, CASP1 antibody, Casp1 antibody, CASP4 antibody, Dcp-1 antibody, Caspase1 antibody, LOC5564196 antibody, LOC451519 antibody

Background: Name/Gene ID: CASP1
Subfamily: Cysteine C14
Family: Protease

Synonyms: CASP1, Caspase-1, CASP-1, CASP1 nirs variant 1, Caspase 1, ICE, ICE-like protease, IL-1 beta-converting enzyme, IL-1BC, IL1BC, IL1BCE, p45, IL1B-convertase, Interleukin-1 beta convertase

Gene ID: 834

UniProt: P29466

Pathways: Apoptosis, Interferon-gamma Pathway, Positive Regulation of Endopeptidase Activity, Inflammasome