CCR3 antibody (C-Term)

Catalog No. ABIN205726

Product Details anti-CCR3 Antibody

Target: CCR3 (Chemokine (C-C Motif) Receptor 3 (CCR3))

Binding Specificity: C-Term

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CCR3 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Specificity: Recognizes human CD193, otherwise known as CC chemokine receptor 3 (CCR3), a seven-helix transmembrane G-protein coupled receptor which, along with and, acts as a principal receptor for the fusion and entry of HIV into target cells. CD193 is expressed by eosinophils, basophils, mast cells, microglia, Th2 helper cells and some epithelial cells. CD193 acts as a receptor for several CC chemokines including monocyte chemoattractant proteins (MCP) -1, -2, -3 and -4, MIP-1a, MIP-1AY, and RANTES. The eotaxin subgroup of CC chemokines act as specific agonists for CD193, and this interaction has become a focus area for studies into the infection of microglia by HIV and allergy research. Has been used successfully for the detection of human CD193 by immunohistochemistry on formalin fixed, paraffin embedded intervertebral disc tissue.

Purification: Purified

Immunogen: Synthetic peptide corresponding to a 14 amino acid sequence located near human CD193 carboxy-terminus.

Type of Immunogen: Synthetic peptide

Isotype: IgG

Application Details

Application Notes: Approved: IHC, IHC-P (10 μg/mL), WB (1 μg/mL)

Usage: Western Blot: LS-C42330 detects a band of approximately 55kD in human spleen cell lysates (predicted MW. 41kD).

Comment:

Target Species of Antibody: Human

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: PBS, 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: avoid freeze thaw cycles. Store undiluted.

Storage: 4 °C,-20 °C

Storage Comment: Short term 4°C, long term aliquot and store at -20°C, avoid freeze-thaw cycles. Store undiluted.

Target Details for CCR3

Target: CCR3 (Chemokine (C-C Motif) Receptor 3 (CCR3))

Alternative Name: CCR3 (CCR3 Products)

Synonyms: CC-CKR-3 antibody, CD193 antibody, CKR3 antibody, CMKBR3 antibody, CC-CKR3 antibody, Cmkbr1l2 antibody, Cmkbr3 antibody, C-C motif chemokine receptor 3 antibody, chemokine (C-C motif) receptor 3 antibody, CCR3 antibody, Ccr3 antibody

Background: Name/Gene ID: CCR3
Subfamily: Chemokine
Family: GPCR

Synonyms: CCR3, C-C chemokine receptor type 3, B-chemokine receptor, CD193, CD193 antigen, Chemokine c-c motif receptor 3, C-C chemokine receptor 3, CKR3, CC-CKR-3, CCR-3, CMKBR3, Eosinophil eotaxin receptor, Eotaxin receptor, C-C CKR-3, CC chemokine receptor 3

Gene ID: 1232

UniProt: P51677