GZMB antibody (Biotin)

Catalog No. ABIN206366

The Mouse Monoclonal anti-GZMB antibody has been validated for IHC, ELISA, FACS, IP and IHC (fro). It is suitable to detect GZMB in samples from Human, Monkey and Rhesus Monkey.

Quick Overview for GZMB antibody (Biotin) (ABIN206366)

Target: GZMB (Granzyme B (GZMB))

Reactivity: Human, Monkey, Rhesus Monkey

Host: Mouse

Clonality: Monoclonal

Conjugate: This GZMB antibody is conjugated to Biotin

Application: Immunohistochemistry (IHC), ELISA, Flow Cytometry (FACS), Immunoprecipitation (IP), Immunohistochemistry (Frozen Sections) (IHC (fro))

Clone: GB10

Product Details anti-GZMB Antibody (Biotin)

Specificity: Recognizes the serine protease Granzyme B, which is expressed within the granules of cytolytic lymphocytes (CTLs). Granzyme B plays a key role in the induction of apoptosis by CTLs. After delivery to the target cell Granzyme B activates the cascade of caspases that finally results in cell death. Has been reported to function as a detection reagent in ELISA assays for soluble Granzyme B in conjunction with GB11 (MCA2120) as capture reagent.

Purification: Protein A purified

Immunogen: Purified human Granzyme B.

Type of Immunogen: Purified protein

Isotype: IgG1

Application Details

Application Notes: Approved: ELISA (1 μg/mL), Flo, IHC, IHC-Fr, IP

Usage: The applications listed have been tested for the unconjugated form of this product. Other forms have not been tested. ELISA: This antibody has been reported to function as a detection reagent in sandwich ELISA assays for soluble Granzyme B in conjunction with GB11 (LS-C44295) as capture reagent.

Comment:

Target Species of Antibody: Human

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: TBS, BSA, 0.001 % Thimerosal

Preservative: Thimerosal (Merthiolate)

Precaution of Use: This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C,-20 °C

Storage Comment: 4°C or -20°C, Avoid freeze-thaw cycles.

Target Details for GZMB

Target: GZMB (Granzyme B (GZMB))

Alternative Name: GZMB / Granzyme B

Background: Name/Gene ID: GZMB
Subfamily: Serine S1
Family: Protease

Synonyms: GZMB, CCPI, CGL-1, Cathepsin G-like 1, CSP-B, CTLA-1, CTLA1, CGL1, CSPB, Fragmentin 2, GRB, HLP, Human lymphocyte protein, Fragmentin-2, SECT, Lymphocyte protease, T-cell serine protease 1-3E, C11, CTSGL1, Cytotoxic serine protease B, Granzyme B, Granzyme-2

Gene ID: 3002

Pathways: Apoptosis, Caspase Cascade in Apoptosis