SOCS3 antibody

Catalog No. ABIN207073

This Mouse Monoclonal antibody specifically detects SOCS3 in WB and Inhibition. It exhibits reactivity toward Human.

Quick Overview for SOCS3 antibody (ABIN207073)

Target: SOCS3 (Suppressor of Cytokine Signaling 3 (SOCS3))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This SOCS3 antibody is un-conjugated

Application: Western Blotting (WB), Blocking Antibody (Inhibition)

Clone: SO1

Product Details anti-SOCS3 Antibody

Specificity: The cytokine signaling is known to be regulated by a negative feedback regulator called suppressor of cytokine signaling (SOCS) inhibitors family. Members of the SOCS family have been identified due to their marked homology on the SH2 domain and a unique conserved motif referred to as the SOCS box. Expression of SOCS3 is transiently induced in a variety of immune and inflammatory situations by a wide variety of cytokines. SOCS3 is also involved in growth hormone function, leptin and insulin signaling. SOCS3 inhibits Janus kinase (JAK) tyrosine kinase activity

Purification: Protein A purified

Immunogen: Full-length SOCS3 protein.

Type of Immunogen: Recombinant protein

Isotype: IgG2b

Application Details

Application Notes: Approved: Inhb, WB

Usage: Western Blotting: Positive control - HeLa human cervix carcinoma cell line. Sample preparation: Resuspend approx. 50 mil. cells in 1 mL cold Lysis buffer (1 % laurylmaltoside in 20 mM Tris/Cl, 100 mM NaCl  pH 8.2, 50 mM NaF including Protease inhibitor Cock

Comment:

Target Species of Antibody: Human

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: PBS, 15 mM sodium azide, approx,  pH 7.4.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: avoid freeze thaw cycles.

Storage: 4 °C,-20 °C

Storage Comment: Short term 4°C, long term aliquot and store at -20°C, avoid freeze-thaw cycles.

Target Details for SOCS3

Target: SOCS3 (Suppressor of Cytokine Signaling 3 (SOCS3))

Alternative Name: SOCS3

Background: Name/Gene ID: SOCS3

Synonyms: SOCS3, Cish3, Cytokine-induced SH2 protein 3, CIS-3, CIS3, SSI-3, STAT-induced STAT inhibitor 3, SSI3, ATOD4, SOCS-3

Gene ID: 9021

UniProt: O14543

Pathways: JAK-STAT Signaling, Response to Growth Hormone Stimulus, Hepatitis C