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Retinoblastoma Protein (Rb) antibody (Cleavage Site)

Name: Retinoblastoma Protein (Rb) antibody (Cleavage Site)
SKU: ABIN207915
Price: 621.13 USD
Availability: InStock

This anti-Retinoblastoma Protein (Rb) antibody is a Mouse Monoclonal antibody detecting Retinoblastoma Protein (Rb) in WB and IHC. Suitable for Human and Mouse.

Image no. 2 for anti-Retinoblastoma Protein (Rb Protein) (Cleavage Site) antibody (ABIN207915) (Retinoblastoma Protein (Rb) antibody (Cleavage Site))

Image no. 1 for anti-Retinoblastoma Protein (Rb Protein) (Cleavage Site) antibody (ABIN207915) (Retinoblastoma Protein (Rb) antibody (Cleavage Site))

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Catalog No. ABIN207915

Quick Overview for Retinoblastoma Protein (Rb) antibody (Cleavage Site) (ABIN207915)

Target

See all Retinoblastoma Protein (Rb) (Rb Protein) Antibodies

Retinoblastoma Protein (Rb) (Rb Protein) (Retinoblastoma Protein (Rb Protein))

Reactivity

Human, Mouse

Host

Mouse

Clonality

Monoclonal

Conjugate

This Retinoblastoma Protein (Rb) antibody is un-conjugated

Application

Western Blotting (WB), Immunohistochemistry (IHC)

Clone

172C1094

Discover our top product Rb Protein Primary Antibody

Binding Specificity
16

13

10

9

9

8

8

7

7

7

4

4

3

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
Cleavage Site

Specificity

Recognizes cleaved Rb (DRb-p70). Does not recognize full-length Rb. In camptothecin treated HL60, an ~68 kD band is observed. DRb-p70 exists in vivo as an N-terminally truncated form of Rb (Liu et al.). DRb-p70 is thought to be the product of alternative translation and is expressed in primary myeloid cells in fetal liver, bone marrow and spleen. DRb-p70 is also specifically expressed in tumor-associated macrophages (TAMs). TAMs are an important targets of cancer therapy. DRb-p70 is a marker of TAMs, and maybe useful for identifying tumors with macrophage infiltration (Liu et al, 2005).

Purification

Protein G purified

Immunogen

A synthetic peptide corresponding to a region of the caspase-3-induced cleavage site of human Rb.

Type of Immunogen: Synthetic peptide

Isotype

IgG1
anti-Retinoblastoma Protein (Rb Protein) (AA 858-886) antibody
Rb Protein Reactivity: Human WB, ELISA, IHC, FACS Host: Rabbit Polyclonal unconjugated

anti-Retinoblastoma Protein (Rb Protein) (pSer811) antibody
Rb Protein Reactivity: Human ELISA, IHC, IF, DB Host: Rabbit Polyclonal unconjugated

anti-Retinoblastoma Protein (Rb Protein) (AA 586-615) antibody
Rb Protein Reactivity: Human WB, ELISA, IHC, IF Host: Rabbit Polyclonal unconjugated

anti-Retinoblastoma Protein (Rb Protein) (pSer608) antibody
Rb Protein Reactivity: Human ELISA, IHC, DB Host: Rabbit Polyclonal unconjugated

anti-Retinoblastoma Protein (Rb Protein) (pSer788) antibody
Rb Protein Reactivity: Human ELISA, IHC, DB Host: Rabbit Polyclonal unconjugated

anti-Retinoblastoma Protein (Rb Protein) (pSer780) antibody
Rb Protein Reactivity: Human ELISA, IHC, DB Host: Rabbit Polyclonal unconjugated

anti-Retinoblastoma Protein (Rb Protein) antibody
Rb Protein Reactivity: Human ELISA, IHC Host: Mouse Monoclonal 7E4B8 unconjugated

anti-Retinoblastoma Protein (Rb Protein) (AA 251-268) antibody
Rb Protein Reactivity: Human, Mouse, Rat, Cow, Dog, Monkey, Pig, Bat, Horse WB Host: Rabbit Polyclonal unconjugated

anti-Retinoblastoma Protein (Rb Protein) (C-Term) antibody
Rb Protein Reactivity: Human, Cow, Dog, Pig, Bat, Guinea Pig WB Host: Rabbit Polyclonal unconjugated

anti-Retinoblastoma Protein (Rb Protein) (N-Term) antibody
Rb Protein Reactivity: Human, Mouse, Monkey WB Host: Rabbit Polyclonal unconjugated

Application Notes

Approved: IHC, WB (2 μg/mL)

Not recommended for: IHC-P

Comment

Target Species of Antibody: Human

Restrictions

For Research Use only
Format

Liquid

Concentration

Lot specific

Buffer

PBS, 0.02 % sodium azide.

Preservative

Sodium azide

Precaution of Use

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage

4 °C,-80 °C

Storage Comment

Short term: 4°C
Long term: -70°C.
Target

Retinoblastoma Protein (Rb) (Rb Protein) (Retinoblastoma Protein (Rb Protein))

Alternative Name

RB1 / Retinoblastoma / RB

Background

Name/Gene ID: RB1

Synonyms: RB1, p105-Rb, Osteosarcoma, PRb, Retinoblastoma, Retinoblastoma 1, OSRC, RB, Pp110

Gene ID

5925

UniProt

P06400

Pathways

Mitotic G1-G1/S Phases