HHV DNA Polymerase Catalytic Subunit (AA 1131-1235) antibody (Alexa Fluor 350)
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- Target
- HHV DNA Polymerase Catalytic Subunit
- Binding Specificity
- AA 1131-1235
- Reactivity
- Human Herpesvirus 1 (HHV-1), Virus
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- Alexa Fluor 350
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Application
- Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
- Specificity
- This antibody will detect both HHV1 and HHV2 DNA polymerase catalytic subunit
- Cross-Reactivity
- Virus
- Cross-Reactivity (Details)
- HHV1
- Purification
- Purified by Protein A.
- Immunogen
- KLH conjugated synthetic peptide derived from human Human herpesvirus 1 DNA polymerase catalytic subunit
- Isotype
- IgG
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- Application Notes
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IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 - Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 μg/μL
- Buffer
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
- Preservative
- ProClin
- Precaution of Use
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Storage
- -20 °C
- Storage Comment
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- Expiry Date
- 12 months
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- Target
- HHV DNA Polymerase Catalytic Subunit
- Target Type
- Viral Protein
- Background
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Synonyms: DPOL_HHV11, DNA polymerase catalytic subunit, UL30, HHV1gp046.
Background: Replicates viral genomic DNA. The replication complex is composed of six viral proteins: the DNA polymerase, processivity factor, primase, primase-associated factor, helicase, and ssDNA-binding protein. Additionally, the polymerase contains an intrinsic ribonuclease H (RNase H) activity that specifically degrades RNA/DNA heteroduplexes or duplex DNA substrates in the 5' to 3' direction. Therefore, it can catalyze the excision of the RNA primers that initiate the synthesis of Okazaki fragments at a replication fork during viral DNA replication.
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