MAGI1 antibody (AA 161-260)
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- Target See all MAGI1 Antibodies
- MAGI1 (Membrane Associated Guanylate Kinase, WW and PDZ Domain Containing 1 (MAGI1))
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Binding Specificity
- AA 161-260
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Reactivity
- Rat
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This MAGI1 antibody is un-conjugated
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Application
- Western Blotting (WB), ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunocytochemistry (ICC)
- Cross-Reactivity
- Rat
- Predicted Reactivity
- Human,Mouse,Dog,Cow,Sheep,Pig,Chicken,Rabbit
- Purification
- Purified by Protein A.
- Immunogen
- KLH conjugated synthetic peptide derived from human MAGI1
- Isotype
- IgG
- Top Product
- Discover our top product MAGI1 Primary Antibody
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- Application Notes
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WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500 - Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 μg/μL
- Buffer
- 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
- Preservative
- ProClin
- Precaution of Use
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Storage
- 4 °C,-20 °C
- Storage Comment
- Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
- Expiry Date
- 12 months
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- Target
- MAGI1 (Membrane Associated Guanylate Kinase, WW and PDZ Domain Containing 1 (MAGI1))
- Alternative Name
- MAGI1/IRSP58 (MAGI1 Products)
- Synonyms
- CNKSR3 antibody, AIP-3 antibody, AIP3 antibody, BAIAP1 antibody, BAP-1 antibody, BAP1 antibody, MAGI-1 antibody, TNRC19 antibody, WWP3 antibody, Baiap1 antibody, Gukmi1 antibody, MAGI1c antibody, Magi-1 antibody, mKIAA4129 antibody, membrane associated guanylate kinase, WW and PDZ domain containing 1 antibody, MAGI1 antibody, Magi1 antibody
- Background
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Synonyms: AIP 3, AIP3, Atrophin 1 interacting protein 3, atrophin-1 interacting protein 3, BAI associated protein 2, BAI1 associated protein 1, BAI1-associated protein 1, BAIAP 1, BAIAP1, BAP 1, BAP1, BAP2, Brain specific angiogenesis inhibitor 1 associated protein 2, Fas ligand associated factor 3, FLAF3,Gukmi1, Insulin receptor substrate p53, Insulin receptor substrate p53/p58, Insulin receptor substrate protein of 53 kDa, IRS 58, IRSP53, IRSp53/58, MAGI 1, MAGI-1, MAGI1c, Membrane associated guanylate kinase inverted 1, membrane associated guanylate kinase inverted-1, membrane associated guanylate kinase WW and PDZ domain containing 1, Protein BAP2, TNRC 19, TNRC19, Trinucleotide repeat containing gene 19, Trinucleotide repeat containing gene 19 protein,trinucleotide repeat-containing gene 19, WW domain containing protein 3, WW domain-containing protein 3, WWP 3, WWP3.
Background: The membrane-associated guanylate kinase (MAGUK) proteins are concentrated at the membrane-cytoskeletal interface where they facilitate the assembly of multiprotein complexes on the inner surface of the plasma membrane. Three protein-protein interaction modules characteristically define MAGUK related proteins: the PDZ domain, the SH3 domain and the guanylate kinase (GuK) domain. The closely related MAGUK proteins, MAGI-1, MAGI-2 and MAGI-3 (membrane associated guanylate kinase inverted-1 and 2), likewise contain the GuK domain and five PDZ domains, however, the SH3 domain is replaced with a WW domain. The transcripts of MAGI-1 are alternatively spliced to produce three distinct proteins having unique C-terminals. Two variants, MAGI-1a and MAGI-1b, are associated with the membrane and cytosolic fractions and are primarily expressed in the brain. The third isoform, MAGI-1c, encodes for a nuclear localization signal that localizes MAGI-1c to the nucleus, and it is primarily expressed in the liver and kidney. MAGI-2 and MAGI-3 are localized to the plasma membrane, and they contribute to protein scaffolding by associating with the protein phosphatase PTEN.
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