Notch3/4 (AA 2001-2100) antibody (Cy7)
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- Target
- Notch3/4
- Binding Specificity
- AA 2001-2100
- Reactivity
- Human, Mouse, Rat
-
Host
- Rabbit
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Clonality
- Polyclonal
-
Conjugate
- Cy7
-
Application
- Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
- Cross-Reactivity
- Human, Mouse, Rat
- Purification
- Purified by Protein A.
- Immunogen
- KLH conjugated synthetic peptide derived from mouse Notch3
- Isotype
- IgG
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-
- Application Notes
-
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 - Restrictions
- For Research Use only
-
- Format
- Liquid
- Concentration
- 1 μg/μL
- Buffer
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
- Preservative
- ProClin
- Precaution of Use
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Storage
- -20 °C
- Storage Comment
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- Expiry Date
- 12 months
-
- Target
- Notch3/4
- Background
-
Synonyms: hNotch 4,hNotch4,NOTCH 3,NOTCH3,INT 3,INT3,MGC74442,Neurogenic locus notch homolog protein 4,Neurogenic locus notch homolog protein 3,NOTC4_HUMAN,NOTCH-3,NOTCH-4,Notch 4 intracellular domain,Notch homolog 4,NOTCH4 protein,Neurogenic locus notch homolog protein 1, CADASIL, CASIL, Notch homolog 3.
Background: NOTCH3 functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBP-J kappa and activates genes of the enhancer of split locus. It affects the implementation of differentiation, proliferation and apoptotic programs. Defects in NOTCH3 are associated with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) (swissprot).
- Gene ID
- 4854
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