RPS6KB2 antibody (pTyr389) (AbBy Fluor® 555)

Catalog No. ABIN2178156

The AbBy Fluor® 555-conjugated Rabbit Polyclonal anti-RPS6KB2 antibody (ABIN2178156) specifically detects RPS6KB2 in WB, IF (p) and IF (cc). The antibody is reactive with Mouse samples.

Quick Overview for RPS6KB2 antibody (pTyr389) (AbBy Fluor® 555) (ABIN2178156)

Target: RPS6KB2 (Ribosomal Protein S6 Kinase, 70kDa, Polypeptide 2 (RPS6KB2))

Reactivity: Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RPS6KB2 antibody is conjugated to AbBy Fluor® 555

Application: Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunofluorescence (Cultured Cells) (IF (cc))

Product Details anti-RPS6KB2 Antibody (AbBy Fluor® 555)

Binding Specificity: pTyr389

Cross-Reactivity: Mouse

Predicted Reactivity: Human,Rat,Dog,Cow,Pig,Horse

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic phosphopeptide derived from human p70 S6 Kinase Beta 2 around the phosphorylation site of Tyr389

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for RPS6KB2

Target: RPS6KB2 (Ribosomal Protein S6 Kinase, 70kDa, Polypeptide 2 (RPS6KB2))

Alternative Name: p70 S6 Kinase Beta 2

Background:

Synonyms: RPS6KB2phospho Y389, S6K phospho Y389, p-S6KTyr389, p70 S6 Kinase Beta 2 phospho Tyr389, 70 kDa ribosomal protein S6 kinase 2, p70 beta, p70 ribosomal S6 kinase beta, p70 S6 kinase beta, p70 S6KB, p70 S6Kbeta, p70S6K beta, p70-beta, p70-S6KB, p70S6Kb, Ribosomal protein S6 kinase 70 kDa, polypeptide 2, Ribosomal protein S6 kinase beta 2, Ribosomal protein S6 kinase beta-2, RPS6KB2, S6 kinase related kinase, S6 kinase-related kinase, S6K beta 2, S6K beta, S6K-beta, S6K2, Serine/threonine protein kinase 14 beta, Serine/threonine-protein kinase 14 beta, SRK, STK14B.

Background: Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the g phosphate of ATP, onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. With more than 500 gene products, the protein kinase family is one of the largest families of proteins in eukaryotes. The family has been classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains.

Pathways: PI3K-Akt Signaling, RTK Signaling, AMPK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway