RAD17 antibody (PE)

Catalog No. ABIN2178768

This anti-RAD17 antibody is a Rabbit Polyclonal antibody detecting RAD17 in FACS. Suitable for Human, Mouse and Rat.

Quick Overview for RAD17 antibody (PE) (ABIN2178768)

Target: RAD17

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RAD17 antibody is conjugated to PE

Application: Flow Cytometry (FACS)

Product Details anti-RAD17 Antibody (PE)

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Rad17

Isotype: IgG

Application Details

Application Notes: FCM: (1:20-100)
Optimal working dilution should be determined by the investigator.

Comment:

Exitation/Emission: 480,565nm/578nm

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 100 μg/mL BSA, 50 % glycerol and 0.09 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at 4 °C for 12 months.

Target Details for RAD17

Target: RAD17

Alternative Name: Rad17

Background: The protein encoded by this gene is highly similar to the gene product of Schizosaccharomyces pombe rad17, a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. This protein shares strong similarity with DNA replication factor C (RFC), and can form a complex with RFCs. This protein binds to chromatin prior to DNA damage and is phosphorylated by the checkpoint kinase ATR following damage. This protein recruits the RAD1-RAD9-HUS1 checkpoint protein complex onto chromatin after DNA damage, which may be required for its phosphorylation. The phosphorylation of this protein is required for the DNA-damage-induced cell cycle G2 arrest, and is thought to be a critical early event during checkpoint signaling in DNA-damaged cells. Multiple alternatively spliced transcript variants of this gene, which encode four distinct protein isoforms, have been reported. Two pseudogenes, located on chromosomes 7 and 13, have been identified. [provided by RefSeq, Jul 2013].
Synonyms: RFC, CCYC, Cell cycle checkpoint protein, Cell cycle checkpoint protein RAD17, HRAD 17, hRad17, R24L, Rad 17, Rad 24, RAD1 S. pombe homolog, RAD17, RAD17 homolog, Rad17 like protein, RAD17_HUMAN, RAD17Sp, Rad24, RF C activator 1 homolog, RF C/activator 1 homolog, RF-C/activator 1 homolog.

Gene ID: 5884