Lamin A/C antibody (C-Term)

Catalog No. ABIN228718

This Rabbit Polyclonal antibody specifically detects Lamin A/C in WB, IHC, ICC and IHC (p). It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for Lamin A/C antibody (C-Term) (ABIN228718)

Target: Lamin A/C (LMNA)

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Lamin A/C antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-Lamin A/C Antibody

Binding Specificity: C-Term

Specificity: Detects endogenous levels of the large fragment of lamin A (and lamin C isotype) resulting from cleavage at Asp230. Does not recognize full length lamin A. Species cross-reactivity: Mouse and rat.

Purification: Protein A purified

Immunogen: Synthetic peptide (KLH coupled) corresponding to C-terminal residues adjacent to Asp230 in human lamin A.

Type of Immunogen: Synthetic peptide

Isotype: IgG

Application Details

Application Notes: Approved: ICC, IHC, IHC-P (1:50), WB (1:1000)

Usage: Western Blot: 1:1000. Immunohistochemistry (Paraffin): 1:50. Immunocytochemistry (ABC) 1:100.

Comment:

Target Species of Antibody: Human

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: 10 mM HEPES,  pH 7.5, 150 mM sodium chloride, 0.1 mg/mL BSA, 50 % glycerol. No preservative added.

Preservative: Without preservative

Handling Advice: Avoid repeat freeze-thaw cycles.

Storage: 4 °C,-20 °C

Storage Comment: Short term: 4°C. Long term: Store at -20°C. Avoid freeze-thaw cycles.

Target Details for Lamin A/C

Target: Lamin A/C (LMNA)

Alternative Name: LMNA / Lamin A/C

Background: Name/Gene ID: LMNA

Synonyms: LMNA, 70 kDa lamin, CDCD1, CMD1A, EMD2, FPLD, IDC, FPL, FPLD2, Lamin A/C, Lamin, LFP, LMNC, LMN1, LMNL1, HGPS, Prelamin-A/C, PRO1, Lamin A, Lamin A/C-like 1, LGMD1B, CDDC, CMT2B1, LDP1

This antibody detects: LMNA / Lamin A+C

Gene ID: 4000

UniProt: P02545

Pathways: Apoptosis, Caspase Cascade in Apoptosis, ER-Nucleus Signaling, Protein targeting to Nucleus