Presenilin 2 antibody

Catalog No. ABIN229144

This Rabbit Polyclonal antibody specifically detects Presenilin 2 in WB, ELISA, IHC, IP and IHC (p). It exhibits reactivity toward Human, Rat, Mouse and Monkey.

Quick Overview for Presenilin 2 antibody (ABIN229144)

Target: Presenilin 2 (PSEN2) (Presenilin 2 (Alzheimer Disease 4) (PSEN2))

Reactivity: Human, Rat, Mouse, Monkey

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Presenilin 2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunoprecipitation (IP), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-Presenilin 2 Antibody

Specificity: Detects endogenous levels of the carboxy-terminal fragment of human presenilin 2 (~20kD) and the full length protein (54kD) to a lesser extent. It does not cross-react with endogenous levels of presenilin 1. Species cross-reactivity: Monkey, mouse and rat.

Purification: Protein A purified

Immunogen: Synthetic peptide (KLH coupled) corresponding to residues surrounding amino acid 330 of human presenilin 2.

Type of Immunogen: Synthetic peptide

Isotype: IgG

Application Details

Application Notes: Approved: ELISA, IHC, IHC-P, IP (1:50), WB (1:1000)

Usage: Suitable for use in Western Blot, ELISA, Immunoprecipitation and Immunohistochemistry. Western Blot: 1:1000. Immunoprecipitation: 1:50. Immunohistochemistry (Paraffin): 1:50.

Comment:

Target Species of Antibody: Human

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: 10 mM HEPES,  pH 7.5, 150 mM sodium chloride, 0.1 mg/mL BSA, 50 % glycerol. No preservative added.

Preservative: Without preservative

Handling Advice: Avoid repeat freeze-thaw cycles.

Storage: 4 °C,-20 °C

Storage Comment: Short term: 4°C. Long term: Store at -20°C. Avoid freeze-thaw cycles.

Target Details for Presenilin 2

Target: Presenilin 2 (PSEN2) (Presenilin 2 (Alzheimer Disease 4) (PSEN2))

Alternative Name: PSEN2 / Presenilin 2

Background: Name/Gene ID: PSEN2
Subfamily: Aspartic A22A
Family: Protease

Synonyms: PSEN2, AD3LP, AD4, AD5, AD3L, CMD1V, PS-2, PSNL2, PS2, STM2, Presenilin 2, STM-2, E5-1, Presenilin-2

Gene ID: 5664

UniProt: P49810

Pathways: Notch Signaling, EGFR Signaling Pathway, Neurotrophin Signaling Pathway