Integrin beta 2 antibody (AA 534-546) (APC)

Catalog No. ABIN231811

This Mouse Monoclonal antibody specifically detects Integrin beta 2 in FACS. It exhibits reactivity toward Human.

Quick Overview for Integrin beta 2 antibody (AA 534-546) (APC) (ABIN231811)

Target: Integrin beta 2 (ITGB2)

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Integrin beta 2 antibody is conjugated to APC

Application: Flow Cytometry (FACS)

Clone: MEM-48

Product Details anti-Integrin beta 2 Antibody (APC)

Binding Specificity: AA 534-546

Specificity: Recognizes an epitope involving residues 534-546 in cysteine-rich repeat 3 of the CD18 antigen (integrin beta2 subunit, beta2 integrin). CD18 is a 90-95 kD type I transmembrane protein expressed on all leukocytes.

Purification: Protein A purified

Immunogen: Leukocytes of a patient suffering from a LGL-type leukemia.

Type of Immunogen: Cells

Isotype: IgG1

Application Details

Application Notes: Approved: Flo

Usage: The reagent is designed for Flow Cytometry analysis of human blood cells using 10 μL reagent / 100 μL of whole blood or 106 cells in a suspension. The content of a vial (1 ml) is sufficient for 100 tests. The applications listed have been tested for the unconjugated form of this product. Other forms have not been tested.

Comment:

Target Species of Antibody: Human

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: PBS, 15 mM sodium azide, 0.2 % high-grade protease free BSA as a stabilizing agent.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Target Details for Integrin beta 2

Target: Integrin beta 2 (ITGB2)

Alternative Name: ITGB2 / MAC-1 / CD18

Background: Name/Gene ID: ITGB2
Family: Integrin

Synonyms: ITGB2, CD18 antigen, CD18, Integrin beta chain, beta 2, LCAMB, MAC-1, MFI7, MF17, Integrin beta-2, LAD, LFA-1

Gene ID: 3689

UniProt: P05107

Pathways: NF-kappaB Signaling, Activation of Innate immune Response, Toll-Like Receptors Cascades, Activated T Cell Proliferation