ERBB3 antibody

Catalog No. ABIN232941

The Mouse Monoclonal anti-ERBB3 antibody (Clone H3-90-6) (ABIN232941) specifically detects ERBB3 in IF, IP and FACS. The antibody is reactive with Human samples.

Quick Overview for ERBB3 antibody (ABIN232941)

Target: ERBB3 (Receptor Tyrosine-Protein Kinase ErbB-3 (ERBB3))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This ERBB3 antibody is un-conjugated

Application: Immunofluorescence (IF), Immunoprecipitation (IP), Flow Cytometry (FACS)

Clone: H3-90-6

Product Details anti-ERBB3 Antibody

Specificity: Does not block the binding of heregulin to c-erbB-31, has no effect on tyrosine kinase activity1, receptor internalization1, or tumorigenic growth of cells overexpressing the cerbB- 32. It is particularly well suited for immunoprecipitation of unoccupied as well as the occupied receptor1. Species cross-reactivity: human.

Purification: Protein A purified

Immunogen: Extracellular fragment of recombinant human c-erbB-3/HER-3 oncoprotein.

Isotype: IgG2a

Application Details

Application Notes: Approved: Flo, IF, IP

Usage: Suitable for use in Flow Cytometry, Immunofluorescence, Immunoprecipitation, Effect on Heregulin (NDF) Binding (Non-inhibitory) and Effect on Tumor Growth (Non-inhibitory). Not suitable for Western Blot. Immunoprecipitation: 2 μg/mg protein lysate. Use Protein A. Well suited for Immunoprecipitation of unoccupied as well as occupied receptor. Positive control: T47D cells. The applications listed have been tested for the unmodified form of this product. Other forms have not been tested.

Not recommended for: IHC-P, WB

Comment:

Target Species of Antibody: Human

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: PBS,  pH 7.4.

Preservative: Azide free

Storage: 4 °C,-20 °C

Storage Comment: Short term: 4°C
Long term: Add glycerol (40-50%) -20°C.

Target Details for ERBB3

Target: ERBB3 (Receptor Tyrosine-Protein Kinase ErbB-3 (ERBB3))

Alternative Name: HER3 / ERBB3

Background: Name/Gene ID: ERBB3
Subfamily: EGF Receptor
Family: Protein Kinase

Synonyms: ERBB3, C-erbB-3, C-erbB3, ErbB-3, HER3, p85-sErbB3, p45-sErbB3, MDA-BF-1, ErbB3-S, LCCS2, p180-ErbB3

Gene ID: 2065

UniProt: P21860

Pathways: RTK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway