ARL6IP1 antibody

Catalog No. ABIN2422671

Product Details anti-ARL6IP1 Antibody

Target: ARL6IP1 (ADP-Ribosylation Factor-Like 6 Interacting Protein 1 (ARL6IP1))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ARL6IP1 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC)

Purification: Affinity purification

Immunogen: Recombinant protein of human ARL6IP1

Isotype: IgG

Application Details

Application Notes: IHC 1:50-1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.4 mg/mL

Buffer: PBS with 0.05 % sodium azide and 50 % glycerol, PH7.4

Preservative: Sodium azide

Handling Advice: Avoid freeze / thaw cycles.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for ARL6IP1

Target: ARL6IP1 (ADP-Ribosylation Factor-Like 6 Interacting Protein 1 (ARL6IP1))

Alternative Name: ARL6IP1 (ARL6IP1 Products)

Synonyms: arl6ip antibody, MGC56593 antibody, zgc:56593 antibody, zgc:77873 antibody, ARL6IP antibody, aip1 antibody, armer antibody, ARL6IP1 antibody, MGC85055 antibody, MGC139614 antibody, DKFZp459O112 antibody, AIP1 antibody, ARMER antibody, AIP-6 antibody, AL022945 antibody, AU042858 antibody, Aip-1 antibody, Arl6ip antibody, C85138 antibody, mKIAA0069 antibody, ADP-ribosylation factor-like 6 interacting protein 1 antibody, ADP ribosylation factor like GTPase 6 interacting protein 1 antibody, ADP ribosylation factor like GTPase 6 interacting protein 1 L homeolog antibody, ADP-ribosylation factor like GTPase 6 interacting protein 1 antibody, arl6ip1 antibody, ARL6IP1 antibody, arl6ip1.L antibody, Arl6ip1 antibody

Background: ARMER (apoptotic regulator in the membrane of the endoplasmic reticulum), also known as ADP-ribosylation-like factor 6-interacting protein 1 (ARL6IP1 or AIP1), is a multi-pass membrane protein that belongs to the Ras superfamily. It is expressed in brain, thymus, lung, bone marrow and, to a lesser extent, in spleen, kidney and liver. ARMER is not found in the heart and is found predominantly in early myeloid progenitor cells localizing to the intracytoplasmic membranes. It interacts with ARL6, inhibits caspase-9 activity by inhibiting proteolysis of downstream substrates (including LEHD-AFC, vimentin and caspase-3) and is down-regulated during myeloid differentiation. ARMER may play a role in membrane trafficking, protein transport or cell signaling during hematopoietic maturation.