CYP3A7 antibody

Catalog No. ABIN2462477

Product Details anti-CYP3A7 Antibody

Target: CYP3A7 (Cytochrome P450, Family 3, Subfamily A, Polypeptide 7 (CYP3A7))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CYP3A7 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Purification: Antibody is purified by protein A chromatography method.

Immunogen: Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human CYP3A7.

Application Details

Application Notes: CYP3A7 antibody can be used for detection of CYP3A7 by ELISA at 1:312500. CYP3A7 antibody can be used for detection of CYP3A7 by western blot at 2.5 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Add 100 ?L of distilled water. Final antibody concentration is 1 mg/mL.

Concentration: 1 mg/mL

Buffer: Antibody is lyophilized in PBS buffer with 2 % sucrose.

Handling Advice: As with any antibody avoid repeat freeze-thaw cycles.

Storage: 4 °C/-20 °C

Storage Comment: For short periods of storage (days) store at 4 °C. For longer periods of storage, store CYP3A7 antibody at -20 °C.

Target Details for CYP3A7

Target: CYP3A7 (Cytochrome P450, Family 3, Subfamily A, Polypeptide 7 (CYP3A7))

Alternative Name: CYP3A7 (CYP3A7 Products)

Synonyms: CP37 antibody, CYPIIIA7 antibody, P450-HFLA antibody, cytochrome P450, family 3, subfamily A, polypeptide 7 antibody, cytochrome P450 family 3 subfamily A member 7 antibody, CYP3A7 antibody

Background: CYP3A7 is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This enzyme hydroxylates testosterone and dehydroepiandrosterone 3-sulphate, which is involved in the formation of estriol during pregnancy. The enzyme also metabolizes some drugs such as aflatoxin B1.This gene, CYP3A7, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This enzyme hydroxylates testosterone and dehydroepiandrosterone 3-sulphate, which is involved in the formation of estriol during pregnancy. The enzyme also metabolizes some drugs such as aflatoxin B1. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. Transcript variants have been described, but it is not known whether these transcripts are normally produced.

Molecular Weight: 57 kDa

Gene ID: 1551

NCBI Accession: NP_000756

UniProt: P24462

Pathways: Steroid Hormone Biosynthesis