PTPN13 antibody (AA 212-399)

Catalog No. ABIN2468004

Product Details anti-PTPN13 Antibody

Target: PTPN13 (Protein tyrosine Phosphatase, Non-Receptor Type 13 (APO-1/CD95 (Fas)-Associated Phosphatase) (PTPN13))

Binding Specificity: AA 212-399

Reactivity: Human

Host: Chicken

Clonality: Polyclonal

Conjugate: This PTPN13 antibody is un-conjugated

Application: Western Blotting (WB)

Purification: Immunoaffinity Purified

Application Details

Application Notes: Protein-tyrosine phosphatase antibody can be used for the detection of Protein-tyrosine phosphatase by Western Blot.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Phosphate-Buffered Saline. No preservatives added.

Preservative: Without preservative

Handling Advice: As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Storage: 4 °C/-20 °C

Storage Comment: PTPN13 antibody can be stored at 4 °C for short term (weeks). Long term storage should be at -20 °C.

Target Details for PTPN13

Target: PTPN13 (Protein tyrosine Phosphatase, Non-Receptor Type 13 (APO-1/CD95 (Fas)-Associated Phosphatase) (PTPN13))

Alternative Name: PTPN13 (PTPN13 Products)

Synonyms: FAP-1 antibody, PNP1 antibody, PTP-BAS antibody, PTP-BL antibody, PTP1E antibody, PTPL1 antibody, PTPLE antibody, hPTP1E antibody, PTPN13 antibody, AI324989 antibody, Ptpri antibody, RIP antibody, Ptp-bl antibody, ptp antibody, wu:fb50g04 antibody, zgc:162319 antibody, protein tyrosine phosphatase, non-receptor type 13 antibody, tyrosine-protein phosphatase non-receptor type 13 antibody, PTPN13 antibody, LOC100540743 antibody, ptpn13 antibody, Ptpn13 antibody

Background: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP is a large protein that possesses a PTP domain at C-terminus, and multiple noncatalytic domains, which include a domain with similarity to band 4.1 superfamily of cytoskeletal-associated proteins, a region consisting of five PDZ domains, and a leucine zipper motif. This PTP was found to interact with, and dephosphorylate Fas receptor, as well as IkappaBalpha through the PDZ domains, which suggested its role in Fas mediated programmed cell death. This PTP was also shown to interact with GTPase-activating protein, and thus may function as a regulator of Rho signaling pathway. Four alternatively spliced transcript variants, which encode distinct proteins, have been reported.

Molecular Weight: 14.2 kDa (calculated)

Gene ID: 5783

NCBI Accession: NP_006255

UniProt: Q12923