DDR1 antibody (C-Term)

Catalog No. ABIN2469321

This anti-DDR1 antibody is a Rabbit Polyclonal antibody detecting DDR1 in IHC. Suitable for Human, Monkey, Pig, Bat, Horse, Cow, Dog, Chimpanzee, Gibbon and Gorilla.

Quick Overview for DDR1 antibody (C-Term) (ABIN2469321)

Target: DDR1 (Discoidin Domain Receptor tyrosine Kinase 1 (DDR1))

Reactivity: Human, Monkey, Pig, Bat, Horse, Cow, Dog, Chimpanzee, Gibbon, Gorilla

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DDR1 antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Product Details anti-DDR1 Antibody

Binding Specificity: C-Term

Specificity: BLAST analysis of the peptide immunogen showed no homology with other human proteins, except DDR2 (69 % ).

Purification: Immunoaffinity Chromatography

Immunogen: DDR1 antibody was raised against a peptide located near the C-Terminal region of DDR1 (Human).

Application Details

Application Notes: DDR1 antibody can be used in ELISA, Western Blot starting at 1 - 2 μg/mL, immunocytochemistry, immunohistochemistry starting at 10 μg/mL, immunoprecipitation starting at 1 - 2 μg/mL, and flow cytometry.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS, 0.1 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: As with all antibodies avoid freeze/thaw cycles.

Storage: 4 °C/-80 °C

Storage Comment: DDR1 antibody should be stored long term (months) at -80 °C and short term (days) at 4 °C.

Target Details for DDR1

Target: DDR1 (Discoidin Domain Receptor tyrosine Kinase 1 (DDR1))

Alternative Name: DDR1

Background: DDR1 is a DDR/TKT type protein kinase. DDR1 is activated by various types of collagen, including types I through IV. Binding of collagen to DDR1 protein results in autophosphorylation and a delayed but sustained tyrosine kinase activation. DDR1 may function in cell-to-cell interaction or recognition. At least three mRNA variants, resulting in different protein isoforms of 875, 913 and 919 amino acids, have been reported. DDR1 protein has been shown to be over expressed in human breast, ovarian, esophageal and pediatric brain tumors.

Gene ID: 780

UniProt: Q08345

Pathways: RTK Signaling, Smooth Muscle Cell Migration