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Metabotropic Glutamate Receptor 5 antibody (N-Term)
GRM5
Reactivity: Rat, Human, Mouse, Chicken, Dog, Monkey, Pig, Bat, Cow, Hamster, Horse, Rabbit, Gibbon
IHC
Host: Rabbit
Polyclonal
unconjugated
Product Details anti-Metabotropic Glutamate Receptor 5 Antibody
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Target
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Metabotropic Glutamate Receptor 5 (GRM5)
(Glutamate Receptor, Metabotropic 5 (GRM5))
Binding Specificity
All epitopes for Metabotropic Glutamate Receptor 5 antibodies
N-Term
Reactivity
Rat, Human, Mouse, Chicken, Dog, Monkey, Pig, Bat, Cow, Hamster, Horse, Rabbit, Gibbon
Host
All hosts for Metabotropic Glutamate Receptor 5 antibodies
Rabbit
Clonality
All clonalities for Metabotropic Glutamate Receptor 5 antibodies
Polyclonal
Conjugate
All conjugates for Metabotropic Glutamate Receptor 5 antibodies
This Metabotropic Glutamate Receptor 5 antibody is un-conjugated
Application
All applications for Metabotropic Glutamate Receptor 5 antibodies
Immunohistochemistry (IHC)
Specificity
BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Purification
Immunoaffinity Chromatography
Immunogen
GRM5 antibody was raised against a peptide located in the N-Terminal extracellular domain of GRM5 (Human).
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Discover our top product GRM5 Primary Antibody
Alternatives
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Application Details
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Application Notes
GRM5 antibody can be used in Western Blot starting at 1:100, and immunohistochemistry starting at 1:100.
Restrictions
For Research Use only
Handling
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Format
Liquid
Buffer
PBS, 0.1 % sodium azide.
Preservative
Sodium azide
Precaution of Use
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice
As with all antibodies avoid freeze/thaw cycles.
Storage
4 °C/-80 °C
Storage Comment
GRM5 antibody should be stored long term (months) at -80 °C and short term (days) at 4 °C.
Target Details for Metabotropic Glutamate Receptor 5
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Target
Metabotropic Glutamate Receptor 5 (GRM5)
(Glutamate Receptor, Metabotropic 5 (GRM5))
Alternative Name
GRM5 (GRM5 Products )
Synonyms
GPRC1E antibody, MGLUR5 antibody, mGlu5 antibody, mGluR5 antibody, mGlur5 antibody, 6430542K11Rik antibody, AI850523 antibody, Glu5R antibody, Gprc1e antibody, mGluR5b antibody, glutamate receptor, metabotropic 5 antibody, glutamate metabotropic receptor 5 antibody, GRM5 antibody, Grm5 antibody
Background
Group I of the Metabotropic Glutamate Receptors includes GRM1 and GRM5, receptors that have been shown to activate phospholipase C. Alternative splice variants of GRM5 have been described, but their full-length nature has not been determined. Inflammation results in the activation of mGluR1 and mGluR5 in dorsal horn neurons of the spinal cord, leading to extracellular signal-regulated kinase (ERK) activation, which is required for nociceptive plasticity and enhanced pain. GRM5 is involved in inflammatory mechanical hyperalgesia and potentially in schizophrenia
Gene ID
2915
UniProt
P41594
Pathways
Regulation of G-Protein Coupled Receptor Protein Signaling , Regulation of long-term Neuronal Synaptic Plasticity
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