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Metabotropic Glutamate Receptor 5 antibody (N-Term)

GRM5 Reactivity: Rat, Human, Mouse, Chicken, Dog, Monkey, Pig, Bat, Cow, Hamster, Horse, Rabbit, Gibbon IHC Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN2469508
  • Target See all Metabotropic Glutamate Receptor 5 (GRM5) Antibodies
    Metabotropic Glutamate Receptor 5 (GRM5) (Glutamate Receptor, Metabotropic 5 (GRM5))
    Binding Specificity
    • 40
    • 26
    • 16
    • 15
    • 12
    • 8
    • 4
    • 4
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    N-Term
    Reactivity
    Rat, Human, Mouse, Chicken, Dog, Monkey, Pig, Bat, Cow, Hamster, Horse, Rabbit, Gibbon
    Host
    • 81
    • 44
    • 2
    • 1
    • 1
    Rabbit
    Clonality
    • 77
    • 52
    Polyclonal
    Conjugate
    • 38
    • 9
    • 8
    • 7
    • 7
    • 5
    • 5
    • 4
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    This Metabotropic Glutamate Receptor 5 antibody is un-conjugated
    Application
    • 110
    • 53
    • 40
    • 33
    • 26
    • 25
    • 19
    • 18
    • 13
    • 13
    • 8
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    Immunohistochemistry (IHC)
    Specificity
    BLAST analysis of the peptide immunogen showed no homology with other human proteins.
    Purification
    Immunoaffinity Chromatography
    Immunogen
    GRM5 antibody was raised against a peptide located in the N-Terminal extracellular domain of GRM5 (Human).
    Top Product
    Discover our top product GRM5 Primary Antibody
  • Application Notes
    GRM5 antibody can be used in Western Blot starting at 1:100, and immunohistochemistry starting at 1:100.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    PBS, 0.1 % sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    As with all antibodies avoid freeze/thaw cycles.
    Storage
    4 °C/-80 °C
    Storage Comment
    GRM5 antibody should be stored long term (months) at -80 °C and short term (days) at 4 °C.
  • Target
    Metabotropic Glutamate Receptor 5 (GRM5) (Glutamate Receptor, Metabotropic 5 (GRM5))
    Alternative Name
    GRM5 (GRM5 Products)
    Synonyms
    GPRC1E antibody, MGLUR5 antibody, mGlu5 antibody, mGluR5 antibody, mGlur5 antibody, 6430542K11Rik antibody, AI850523 antibody, Glu5R antibody, Gprc1e antibody, mGluR5b antibody, glutamate receptor, metabotropic 5 antibody, glutamate metabotropic receptor 5 antibody, GRM5 antibody, Grm5 antibody
    Background
    Group I of the Metabotropic Glutamate Receptors includes GRM1 and GRM5, receptors that have been shown to activate phospholipase C. Alternative splice variants of GRM5 have been described, but their full-length nature has not been determined. Inflammation results in the activation of mGluR1 and mGluR5 in dorsal horn neurons of the spinal cord, leading to extracellular signal-regulated kinase (ERK) activation, which is required for nociceptive plasticity and enhanced pain. GRM5 is involved in inflammatory mechanical hyperalgesia and potentially in schizophrenia
    Gene ID
    2915
    UniProt
    P41594
    Pathways
    Regulation of G-Protein Coupled Receptor Protein Signaling, Regulation of long-term Neuronal Synaptic Plasticity
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