ITGA4 antibody (C-Term)

Catalog No. ABIN2469523

This Rabbit Polyclonal antibody specifically detects ITGA4 in IHC. It exhibits reactivity toward Human, Mouse, Rat, Dog, Monkey, Pig, Rabbit, Bat, Hamster, Gibbon and Gorilla.

Quick Overview for ITGA4 antibody (C-Term) (ABIN2469523)

Target: ITGA4 (Integrin alpha 4 (ITGA4))

Reactivity: Human, Mouse, Rat, Dog, Monkey, Pig, Rabbit, Bat, Hamster, Gibbon, Gorilla

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ITGA4 antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Product Details anti-ITGA4 Antibody

Binding Specificity: C-Term

Specificity: BLAST analysis of the peptide immunogen showed no homology with other human proteins.

Purification: Immunoaffinity Chromatography

Immunogen: Integrin alpha 4 antibody was raised against a peptide located in the C-Terminal domain of Integrin alpha 4 (Human).

Application Details

Application Notes: Integrin alpha 4 antibody can be used in ELISA, Western Blot starting at 1:500 - 1:1000, and immunohistochemistry starting at 5 μg/mL.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS, 0.1 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: As with all antibodies avoid freeze/thaw cycles.

Storage: 4 °C/-80 °C

Storage Comment: Integrin alpha 4 antibody should be stored long term (months) at -80 °C and short term (days) at 4 °C.

Target Details for ITGA4

Target: ITGA4 (Integrin alpha 4 (ITGA4))

Alternative Name: Integrin alpha 4

Background: ITGA4 encodes integrin alpha chain 4. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Unlike other integrin alpha chains, alpha 4 neither contains an I-domain, nor undergoes disulfide-linked cleavage. Although alpha 4 is variably cleaved to yield two unlinked chains, this cleavage is unnecessary for integrin assembly and function. Alpha 4 combines with beta 1 (ITGB1) on T-cells to form the integrin very late (activation) antigen 4 (VLA-4) that can bind to the extracellular matrix molecules fibronectin or thrombospondin, and is also a ligand for the cell surface molecule vascular cell adhesion molecule 1 (VCAM-1). In addition, alpha 4 combines with beta 7 to form the lymphocyte homing receptor known as LPAM-1 (lymphocyte Peyer Patch adhesion molecule 1). Integrins are also known to participate in cell-surface mediated signalling.

Gene ID: 3676

UniProt: P13612

Pathways: Integrin Complex