ATM antibody (AA 980-1152)

Catalog No. ABIN2469773

The Mouse Monoclonal anti-ATM antibody has been validated for WB, IHC and IP. It is suitable to detect ATM in samples from Human.

Quick Overview for ATM antibody (AA 980-1152) (ABIN2469773)

Target: ATM (Ataxia Telangiectasia Mutated (ATM))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This ATM antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP)

Clone: 3-00E-008

Product Details anti-ATM Antibody

Binding Specificity: AA 980-1152

Purification: Protein G Column

Immunogen: ATM monoclonal antibody was raised against recombinant protein expressed in E. coli, amino acids 980 - 1512 of ATM (Human).

Isotype: IgG1

Application Details

Application Notes: ATM antibody can be used in ELISA starting at 1:200 - 1:1000, Western Blot starting at 1:100 - 1:300, immunocytochemistry starting at 1:75, and immunofluorescence starting at 1:25 - 1:50.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS, pH 7.4. No preservatives added.

Preservative: Without preservative

Handling Advice: As with all antibodies avoid freeze/thaw cycles.

Storage: -20 °C

Storage Comment: Store ATM antibody at -20 °C.

Target Details for ATM

Target: ATM (Ataxia Telangiectasia Mutated (ATM))

Alternative Name: ATM

Background: ATM-3E8 recognizes full-length ATM, a 370 kDa nuclear phosphoprotein, which is involved in the autosomal recessive disease ataxia telangiectasia (AT). ATM belongs to a novel family of proteins associated with cell cycle regulation and response to DNA repair. The C-terminal region has extensive homology to the catalytic domains of phosphatidylinositol 3-kinases (PI3 kinases). Its usefulness to monitor altered ATM expression in cancer is under active investigation. The ATM gene product is a 370 kD nuclear phosphoprotein with C-terminal homology to phosphatidylinositol 3-kinase. ATM is involved in the induction of a DNA damage control pathway. Mutations in the ATM gene cause neuronal degeneration, gonadal abnormalities, and immune deficiencies as part of the hereditary disease ataxia telangiectasia.

Gene ID: 472

UniProt: Q13315

Pathways: p53 Signaling, Apoptosis, DNA Damage Repair, Inositol Metabolic Process, Positive Regulation of Response to DNA Damage Stimulus