TLR8 antibody (AA 750-850)

Catalog No. ABIN2470503

This anti-TLR8 antibody is a Mouse Monoclonal antibody detecting TLR8 in WB, IHC and FACS. Suitable for Human and Mouse.

Quick Overview for TLR8 antibody (AA 750-850) (ABIN2470503)

Target: TLR8 (Toll-Like Receptor 8 (TLR8))

Reactivity: Human, Mouse

Host: Mouse

Clonality: Monoclonal

Conjugate: This TLR8 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Flow Cytometry (FACS)

Clone: 44C143

Product Details anti-TLR8 Antibody

Binding Specificity: AA 750-850

Purification: Protein G Column

Immunogen: TLR8 monoclonal antibody was raised against amino acids 750 - 850 of TLR8 (Human).

Isotype: IgG kappa

Application Details

Application Notes: TLR8 antibody can be used in immunohistochemistry starting at 1:100, and flow cytometry.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: 0.2 mLPBS, 0.05 % BSA, 0.05 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: As with all antibodies avoid freeze/thaw cycles.

Storage: 4 °C/-20 °C

Storage Comment: Store TLR8 antibody at 4 °C or -20 °C.

Target Details for TLR8

Target: TLR8 (Toll-Like Receptor 8 (TLR8))

Alternative Name: TLR8

Background: Ten human homologs of TLRs (TLR1-10) have been described. TLR8 gene contains three exons, two of which have coding function. TLR8 cDNA codes for a protein of approximate molecular weight of 120 kDa (4,5). Toll-like receptors (TLRs) are signaling molecules that recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses. These proteins act through adaptor molecules such as MyD88 and TIRAP to activate various kinases and transcription factors. Like TLR7, TLR8 is localized to endosomal or lysosomal compartments and stimulates the innate immune response after activation by guanosine- and uridine-rich single-stranded RNA. Human but not murine TLR8 confers responsiveness to the antiviral compound R-848. The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is predominantly expressed in lung and peripheral blood leukocytes, and lies in close proximity to another family member, TLR7, on chromosome X.

Gene ID: 51311

UniProt: Q9NR97

Pathways: TLR Signaling, Activation of Innate immune Response, Toll-Like Receptors Cascades